The developmental precursors of the nose are the neural crest cells, which commence their caudad migration toward the midface around the fourth week of gestation. Two nasal placodes develop inferiorly in a symmetrical fashion. Nasal pits divide the placodes into medial and lateral nasal processes. The medial processes become the septum, philtrum, and premaxilla of the nose, whereas the lateral processes form the sides of the nose. Inferior to the nasal complex, the stomodeum, or future mouth, forms. (See the image below.)
A nasobuccal membrane separates the oral cavity inferiorly from the nasal cavity superiorly. As the olfactory pits deepen, the choanae are formed. Primitive choanae form initially, but with continued posterior development, the secondary, or permanent, choanae develop. By 10 weeks, differentiation into muscle, cartilage, and bony elements occurs. Failure of these carefully orchestrated events in early facial embryogenesis may result in multiple potential anomalies, including choanal atresia, medial or lateral nasal clefts, nasal aplasia, and polyrrhinia.  Neonates are obligate nasal breathers for the first 6 weeks. When bilateral choanal atresia is present in a neonate, emergency action is needed.
Like the underlying bony-cartilaginous framework of the nose, the overlying skin may also be divided into vertical thirds. The skin of the upper third is fairly thick but tapers into a thinner, mid-dorsal region. The inferior third regains the thickness of the upper third owing to the more sebaceous nature of the skin in the nasal tip. The dorsal skin is usually the thinnest of the 3 sections of the nose. The difference in the skin thickness must be appreciated during dorsal reduction.
The nasal muscles are encountered deep to the skin and consist of 4 principal groups: the elevators, the depressors, the compressor, and the dilators. The elevators include the procerus and levator labii superioris alaeque nasi. The depressors are made up of the alar nasalis and depressor septi nasi. The compressor of the nose is the transverse nasalis, whereas the dilators are the dilator naris anterior and posterior. The muscles are interconnected by an aponeurosis termed the nasal superficial musculoaponeurotic system (SMAS).
The internal nasal lining consists of squamous epithelium in the vestibule. This transitions to pseudostratified ciliated columnar respiratory epithelium with abundant seromucinous glands within the nose.
The external soft tissue of the nose can be divided into subunits. The purpose of subunits is to divide the nasal anatomy into segments useful for reconstruction. If more than 50% of the subunit is lost, one would strive to replace the whole unit with regional tissue or tissue from a donor site. The subunits include the dorsal nasal segment, lateral nasal wall segments, the hemilobule segment, soft tissue triangle segments, the alar segments and the columellar segment. (See the image below.)
The nose, like the rest of the face, has an abundant blood supply. The arterial supply to the nose may be principally divided into (1) branches from the internal carotid, namely the branches of the anterior and posterior ethmoid arteries from the ophthalmic artery, and (2) branches from the external carotid, namely the sphenopalatine, greater palatine, superior labial, and angular arteries.
The external nose is supplied by the facial artery, which becomes the angular artery coursing over the superomedial aspect of the nose. The sellar and dorsal regions of the nose are supplied by branches of the internal maxillary artery (namely, the infraorbital) and ophthalmic arteries (which are from the internal carotid system).
Internally, the lateral nasal wall is supplied by the sphenopalatine artery posteroinferiorly and by the anterior and posterior ethmoid arteries superiorly. The nasal septum also derives its blood supply from the sphenopalatine and the anterior and posterior ethmoid arteries with the added contribution of the superior labial artery (anteriorly) and the greater palatine artery (posteriorly). The Kiesselbach plexus, or the Little area, represents a region in the anteroinferior third of the nasal septum, where all 3 of the chief blood supplies to the internal nose converge.
Veins in the nose essentially follow the arterial pattern. They are significant for their direct communication with the cavernous sinus and for their lack of valves; these features potentiate the intracranial spread of infection. Even with the abundant blood supply of the nose, smoking does compromise postoperative healing.
Lymphatics arise from the superficial mucosa and drain posteriorly to the retropharyngeal nodes and anteriorly to the upper deep cervical nodes and/or submandibular glands
The sensation of the nose is derived from the first 2 branches of the trigeminal nerve. The following outline effectively delineates the respective sensory distribution of the nose and face of the trigeminal nerve.
The ophthalmic division includes the following:
Lacrimal – Skin of lateral orbital area except lacrimal gland
Frontal – Skin of forehead and scalp, including the supraorbital (eyelid skin, forehead, scalp) and supratrochlear (medial eyelid, medial forehead) skin
Nasociliary – Skin of the nose and mucous membrane of anterior nasal cavity.
On a more detailed level, the nasociliary portion of the ophthalmic division includes the following:
Anterior ethmoid – Anterior half of nasal cavity: (1) internal – ethmoid and frontal sinuses and (2) external – nasal skin from rhinion to tip
Posterior ethmoid – Superior half of nasal cavity, namely the sphenoid and ethmoids
Intratrochlear – Medial eyelids, palpebral conjunctiva, nasion, and bony dorsum
The maxillary division includes the following:
Infraorbital – External nares
Superior posterior dental
Superior anterior dental – Mediates sneeze reflex
Sphenopalatine – Divides into lateral and septal branches and conveys sensation from posterior and central regions of the nasal cavity
Parasympathetic nerve supply
The parasympathetic supply is derived from the greater superficial petrosal (GSP) branch of cranial nerve VII. The GSP joins the deep petrosal nerve (sympathetic supply), which comes from the carotid plexus to form the vidian nerve in the vidian canal. The vidian nerve travels through the pterygopalatine ganglion (with only the parasympathetic nerves forming synapses here) to the lacrimal gland and glands of the nose and palate via the maxillary division of the trigeminal nerve.
Superiorly, the paired nasal bones are attached to the frontal bone (see the images below). Superolaterally, they are connected to the lacrimal bones, and inferolaterally, they are attached to the ascending processes of the maxilla. Posterosuperiorly, the bony nasal septum is composed of the perpendicular plate of the ethmoid, shown in the second image below. Posteroinferiorly lies the vomer, which in part forms the choanal opening into the nasopharynx. The floor consists of the premaxilla and the palatine bones.
The lateral nasal walls contain 3 pairs each of small, thin, shell-like bones: the superior, middle, and inferior conchae, which form the bony framework of the turbinates. Lateral to these curved structures lies the medial wall of the maxillary sinus.
Inferior to the turbinates lies a space called a meatus, with names that correspond to the above turbinate, eg, superior turbinate, superior meatus. The roof of the nose internally is formed by the cribriform plate of the ethmoid. Posteroinferior to this structure, sloping down at an angle, is the bony face of the sphenoid sinus.
The cartilaginous septum extends from the nasal bones in the midline above to the bony septum in the midline posteriorly, then down along the bony floor. It assumes a quadrangular shape. Its upper half is flanked by 2 triangular-to-trapezoidal cartilages, called the upper lateral cartilages, which are fused to the dorsal septum in the midline and attached to the bony margin of the pyriform aperture laterally by loose ligaments. The inferior ends of the upper lateral cartilages are free. The internal area or angle formed by the septum and upper lateral cartilage constitutes the internal valve. Adjacent sesamoid cartilages may be found lateral to the upper lateral cartilages in the fibroareolar connective tissue. These are found variably.
Beneath the upper lateral cartilages lie the lower lateral cartilages, shown below. The paired lower lateral cartilages swing out from medial attachments to the caudal septum in the midline, called the medial crura, to an intermediate crus area. They finally flare out superolaterally as the lateral crura. These cartilages are frequently mobile, in contradistinction to the upper lateral cartilages.
In some individuals, evidence of a scroll may exist, that is, an outcurving of the lower borders of the upper lateral cartilages and an incurving of the cephalic borders of the alar cartilages. Several variations exist, as depicted below.
The first image below depicts the external nasal anatomy. Nasal subunits include the dorsum, sidewalls, hemilobules, alae, soft triangles, and columella.  Ethnic influences can result in different appearances of the nose,  as follows: Caucasian, leptorrhine; African American, platyrrhine; Hispanic, paraleptorrhine; and Asian, subplatyrrhine. The external valve is a variable area dependent on the size, shape, and strength of the lower lateral cartilage.
The septum is a midline bony and cartilaginous structure that divides the nose into 2 similar halves. Regarding the lateral nasal wall and paranasal sinuses, the superior, middle, and inferior concha form corresponding superior, middle, and inferior meatus on the lateral nasal wall. The superior meatus is the drainage area for the posterior ethmoid cells and the sphenoid sinus. The middle meatus provides drainage of anterior ethmoid and the maxillary and frontal sinuses. The inferior meatus provides drainage of the nasolacrimal duct. 
The internal nasal valve involves the area bounded by upper lateral cartilage, septum, nasal floor, and anterior head of the inferior turbinate. This makes up the narrowest portion of the nasal airway in the leptorrhine nose. Generally, an angle wider than 15° is needed in this area. The width of the nasal valve can be increased with spreader grafts and flaring sutures.
The nose can be conveniently divided into several subunits: the dorsum, sidewalls (paired), hemilobules (paired), soft triangles (paired), alae (paired), and columella (see the image below). Viewing the external nasal anatomy by its subunits is important, because defects that span an entire subunit are usually repaired with reconstruction of that subunit.
Burget suggests replacement of the entire subunit if more than 50% of the subunit is lost during resection.  Aesthetically, the nose—from the nasion (nasofrontal junction) to the columella-labial junction—ideally occupies one third of the face in the vertical dimension. From ala to ala, it should ideally occupy one fifth of the horizontal dimension of the face.
The nasofrontal angle between the frontal bone and nasion is usually 120° and slightly more acute in males than in females. The nasofacial angle, or the slope of the nose compared with the plane of the face, is approximately 30-40°. The nasolabial angle between the columella and philtrum is about 90-95° in males and 100-105° in females.
On profile view, normal columella show, ie, the height of the nasal aperture visible, is 2-4 mm. The dorsum should be straight. From below, the alar base forms an isosceles triangle, with the apex at the infratip lobule just beneath the tip. Appropriate projection of the nasal tip, or the distance of the tip from the face, is judged by using the Goode rule. Tip projection should be 55-60% of the distance between the nasion and tip-defining point. A columellar double break may be present, marking the transition between the intermediate crus of the lower lateral cartilage and the medial crus.
Hengerer AS, Oas RE. Congenital anomalies of the nose: Their embryology, diagnosis, and management (SIPAC). Alexandria, Va: American Academy of Otolaryngology; 1987.
Jafek BW. Anatomy and physiology of the nose. Jafek BW, Stark AK, eds. ENT Secrets. Philadelphia, Pa: Hanley & Belfus; 1996. 77-83.
Heidari Z, Mahmoudzadeh-Sagheb H, Khammar T, Khammar M. Anthropometric measurements of the external nose in 18-25-year-old Sistani and Baluch aborigine women in the southeast of Iran. Folia Morphol (Warsz). 2009 May. 68(2):88-92. [Medline].
Burget GC, Menick FJ. The subunit principle in nasal reconstruction. Plast Reconstr Surg. 1985 Aug. 76(2):239-47. [Medline].
Edward W Chang, MD, DDS, FACS Consulting Staff, Department of Cosmetic Services, Head and Neck Surgery, Kaiser Permanente of Northern California at Santa Rosa
Edward W Chang, MD, DDS, FACS is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American College of Surgeons, California Medical Association, American Academy of Otolaryngology-Head and Neck Surgery
Disclosure: Nothing to disclose.
Chau T Nguyen, MD Clinical Assistant Professor, Division of Head and Neck Surgery, University of California, Los Angeles, David Geffen School of Medicine; Director of Otolaryngology-Head and Neck Surgery, Ventura County Medical Center
Chau T Nguyen, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American College of Surgeons, American Head and Neck Society, American Medical Association, California Medical Association, Phi Beta Kappa
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Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference
Disclosure: Received salary from Medscape for employment. for: Medscape.
Dominique Dorion, MD, MSc, FRCSC, FACS Deputy Dean and Associate Dean of Resources, Professor of Surgery, Division of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Université de Sherbrooke, Canada
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Arlen D Meyers, MD, MBA Professor of Otolaryngology, Dentistry, and Engineering, University of Colorado School of Medicine
Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American Head and Neck Society
Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Cerescan;RxRevu;Cliexa;Preacute Population Health Management;The Physicians Edge<br/>Received income in an amount equal to or greater than $250 from: The Physicians Edge, Cliexa<br/> Received stock from RxRevu; Received ownership interest from Cerescan for consulting; for: Rxblockchain;Bridge Health.
Eric J Moore, MD, FACS Residency Director, Associate Professor, Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Graduate School of Medicine
Eric J Moore, MD, FACS is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Head and Neck Society, American Academy of Otolaryngology-Head and Neck Surgery, American Cleft Palate-Craniofacial Association
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Samuel M Lam, MD, FACS Department of Otolaryngology, Facial Plastic Surgery, Presbyterian Hospital of Plano
Samuel M Lam, MD, FACS, is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery and International Society of Hair Restoration Surgery
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