Multinucleate Cell Angiohistiocytoma

Multinucleate Cell Angiohistiocytoma

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Multinucleate cell angiohistiocytoma is a benign fibrohistiocytic and vascular proliferation that was first reported by Smith and Wilson Jones in 1985. [1] Multinucleate cell angiohistiocytoma occurs predominantly on the extremities of middle-aged and elderly women.

The pathogenesis of multinucleate cell angiohistiocytoma is unknown. Some authors consider it a connective-tissue disorder, while others categorize it as a vascular tumor. Wilson Jones concluded that multinucleate cell angiohistiocytoma is a chronic inflammatory disorder of unknown cause manifested by vascular hyperplasia and connective-tissue cells that have lost their function after prolonged stimulation. Cesinaro et al argue for a role played by estrogen in the development of this lesion. [2]

Multinucleate cell angiohistiocytoma is a rare disorder. Fewer than 100 cases have been reported as of 2015. [3, 4, 5, 6, 7, 8]

The frequency of multinucleate cell angiohistiocytoma in various races has not been reported.

The female-to-male ratio of persons affected with multinucleate cell angiohistiocytoma is approximately 5:1.

Reported cases of multinucleate cell angiohistiocytoma have occurred in patients aged 24-74 years. Most cases of multinucleate cell angiohistiocytoma occur in middle-aged and elderly women.

Multinucleate cell angiohistiocytoma is a benign condition. Spontaneous resolution is uncommon. No morbidity or mortality is associated with multinucleate cell angiohistiocytoma.

Smith NP, Wilson Jones E. Multinucleate cell angiohistiocytoma: a new entity. Br J Dermatol. 1985. 113(suppl 29):15.

Cesinaro AM, Roncati L, Maiorana A. Estrogen receptor alpha overexpression in multinucleate cell angiohistiocytoma: new insights into the pathogenesis of a reactive process. Am J Dermatopathol. 2010 Oct. 32(7):655-9. [Medline].

Aloi F, Solaroli C, Tomasini C, Pippione M. Multinucleate cell angiohistiocytoma: a report of two cases. J Eur Acad Dermatol Venereol. 1998 Jul. 11(1):51-4. [Medline].

Blanco Barrios S, Rodriguez Diaz E, Alvarez Cuesta C, Galache Osuna C, Requena Caballero C, Martinez Merino A, et al. Multinucleate cell angiohistiocytoma: a new case report. J Eur Acad Dermatol Venereol. 2005 Mar. 19(2):208-11. [Medline].

Cribier B, Gambini C, Rainero M, Grosshans E. Multinucleate cell angiohistiocytoma. A review and report of four cases. Acta Derm Venereol. 1995 Sep. 75(5):337-9. [Medline].

Jaconelli L, Kanitakis J, Ktiouet S, Faure M, Claudy A. Multinucleate cell angiohistiocytoma: report of three new cases and literature review. Dermatol Online J. 2009 Feb 15. 15(2):4. [Medline].

Väkevä L, Saksela O, Kariniemi AL. Multinucleate cell angiohistiocytoma: a report of four cases in Finland. Acta Derm Venereol. 2003. 83(3):222-3. [Medline].

Doane JA, Purdy K, Pasternak S. Generalized Multinucleate Cell Angiohistiocytoma. J Cutan Med Surg. 2015 May-Jun. 19 (3):323-5. [Medline].

Jones AC, Mullins D, Jimenez F. Multinucleate cell angiohistiocytoma of the upper lip. Oral Surg Oral Med Oral Pathol. 1994 Dec. 78(6):743-7. [Medline].

Rawal YB, Anderson KM, Rawal SY. Multinucleate cell angiohistiocytoma: an uncommon mucosal tumour. Clin Exp Dermatol. 2009 Apr. 34(3):333-6. [Medline].

Shields JA, Eagle RC Jr, Shields CL, Sohmer KK. Multinucleate cell angiohistiocytoma of the orbit. Am J Ophthalmol. 1995 Sep. 120(3):402-3. [Medline].

Puig L, Fernandez-Figueras MT, Bielsa I, Lloveras B, Alomar A. Multinucleate cell angiohistiocytoma: a fibrohistiocytic proliferation with increased mast cell numbers and vascular hyperplasia. J Cutan Pathol. 2002 Apr. 29(4):232-7. [Medline].

Shapiro PE, Nova MP, Rosmarin LA, Halperin AJ. Multinucleate cell angiohistiocytoma: a distinct entity diagnosable by clinical and histologic features. J Am Acad Dermatol. 1994 Mar. 30(3):417-22. [Medline].

Jones WE, Cerio R, Smith NP. Multinucleate cell angiohistiocytoma: an acquired vascular anomaly to be distinguished from Kaposi’s sarcoma. Br J Dermatol. 1990 May. 122(5):651-63. [Medline].

Kopera D, Smolle J, Kerl H. Multinucleate cell angiohistiocytoma: treatment with argon laser. Br J Dermatol. 1995 Aug. 133(2):308-10. [Medline].

Richer V, Lui H. Facial multinucleate cell angiohistiocytoma: long-term remission with 585 nm pulsed dye laser. Clin Exp Dermatol. 2016 Apr. 41 (3):312-3. [Medline].

Fernandez-Jorge B, del Pozo J, Garcia-Silva J, Barja JM, Yebra-Pimentel MT, Fonseca E. Multinucleate cell angiohistiocytoma: treatment using intense pulsed light. Dermatol Surg. 2009 Jul. 35(7):1141-3. [Medline].

Perez LP, Zulaica A, Rodriguez L, et al. Multinucleate cell angiohistiocytoma. Report of five cases. J Cutan Pathol. 2006 May. 33(5):349-52. [Medline].

Diane M Scott, MD Dermatologist, Arch Health Partners

Diane M Scott, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Daniel Davis, MD Associate Professor, Departments of Dermatology, Otolaryngology, and Pathology, University of Arkansas for Medical Science

Disclosure: Nothing to disclose.

David F Butler, MD Former Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Society for MOHS Surgery, Association of Military Dermatologists, Phi Beta Kappa

Disclosure: Nothing to disclose.

Paul Krusinski, MD Director of Dermatology, Fletcher Allen Health Care; Professor, Department of Internal Medicine, University of Vermont College of Medicine

Paul Krusinski, MD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Received income in an amount equal to or greater than $250 from: Elsevier; WebMD.

Abdul-Ghani Kibbi, MD Professor and Chair, Department of Dermatology, American University of Beirut Medical Center, Lebanon

Disclosure: Nothing to disclose.

Frances Ramos-Ceballos Staff Physician, Department of Dermatology, University of Arkansas for Medical Sciences

Frances Ramos-Ceballos is a member of the following medical societies: American Academy of Dermatology, Phi Beta Kappa, and Women’s Dermatologic Society

Disclosure: Nothing to disclose.

Multinucleate Cell Angiohistiocytoma

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