MRI for Anterior Cruciate Ligament Injury

MRI for Anterior Cruciate Ligament Injury

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The anterior cruciate ligament (ACL) is the most commonly injured of the major knee ligaments. These injuries plague both athletes and nonathletes. The ACL is a vital ligamentous stabilizer of the knee that resists anterior translation and secondarily resists varus and valgus forces. [1] The ACL also functions as a mechanoreceptor that relays information about knee tension to the central nervous system. Patients with ACL injury have variable knee instability that may limit even ordinary daily activities. They experience particular difficulty pivoting and ambulating on uneven surfaces. The torn ACL undergoes limited healing. Long-term morbidity is common with sequelae including osteoarthritis and secondary meniscal tears. [2, 3, 4, 5, 6]

See the image below.

See Football Injuries: Slideshow, a Critical Images slideshow, to help diagnose and treat injuries from a football game that can result in minor to severe complications.

A primary role of MRI in the management of the patient with an ACL injury lies in allowing confident diagnosis or exclusion of a tear in patients with equivocal physical examination findings. It should be emphasized, however, that ACL injury management is critically dependent on accurate diagnosis of other coexisting knee internal derangements, in particular tears of the lateral collateral ligament (LCL), posterior cruciate ligament (PCL), and the menisci. [7] Patients with combined LCL/ACL or PCL/ACL injuries often have profound instability requiring aggressive surgical management.  In the instance of a coexisting LCL tear, intervention may be hastened as LCL injuries are optimally repaired within 1-3 weeks. An unoperated LCL tear predisposes an ACL graft to early failure. [8, 9, 10, 11]

See the image below.

Relevant to the discussion above, Vincken et al point out that it is the evaluation of the knee joint as a whole (the composite diagnosis) that is central to appropriate selection of patients for therapeutic arthroscopy. The high reported composite sensitivity and specificity of knee MRI (87-94% and 88-93%, respectively) indicates MRI should serve well in this role. [7, 12] A study by Thomas et al concluded that while MRI may be overused in high-probability ACL-meniscal injury settings, a negative MRI largely excludes derangements that will benefit from arthroscopy. [13]

While accurate in the diagnosis of ACL injury, MRI findings are not helpful in ruling in or ruling out knee instability. Evaluation of instability enters strongly into the decision to opt for conservative or surgical treatment, and this remains a clinical assessment. [14]

The skilled clinician can diagnose as many as 90% of ACL tears based on history and physical examination findings. [15, 16] Patients typically report an audible pop and “giving way” at the time of injury. A knee effusion usually develops over the next 24 hours. A tear is confirmed by physical examination, primarily by performing the Lachman test. [1] The anterior drawer and pivot shift tests are often helpful, and arthrometric examination may be contributory. Arthroscopy and arthrotomy are the criterion standards for diagnosis, but they are obviously more invasive and costly. [17, 18, 19, 20, 21]

Physical diagnosis is particularly difficult in large patients, in patients with strong secondary muscular restraints, and in patients with an acute injury and soft-tissue swelling and guarding. Partial ACL tears are also difficult to diagnose on physical examination. [22] MRI may provide pivotal diagnostic information about the ACL in all of these settings. [7, 23]

Treatment of ACL tears ranges from conservative therapies (bracing and physical rehabilitation) to surgical ACL reconstruction. [24] More limited surgical interventions such as native ligament repair or augmentation have gained little traction in the orthopedic community.

The patient’s activity level (and expectation for activity in the future) is the most important factor guiding the choice of treatment. [1] Associated meniscal and ligamentous injuries, the degree of laxity, and the patient’s age and willingness to pursue vigorous postoperative physical therapy are other major determinants.

ACL graft reconstruction stabilizes the ACL-deficient knee, thus increasing the range of activities tolerated and preventing reinjury from repeated subluxation. ACL reconstruction, however, has not been proven definitively to prevent long-term osteoarthritic deterioration. [1, 25]  A study by Potter et al provides some evidence of chondroprotective effects of surgery in the medial and patellofemoral compartments. This study, however, concluded that all patients with an ACL injury incur articular chondral injuries and that variable progression of osteoarthritis develops over time in any or all of the 3 knee compartments, accelerating at 5-7 years after injury. [26]

ACL reconstruction is typically delayed several weeks or months until swelling has subsided and range of motion is restored. It is purported that late surgery decreases postprocedural stiffness; however, the effect on long-term outcomes is less clear. [1]  Longer delays before surgery (>1 year) have been associated with an increasing incidence of various internal derangements, especially medial meniscal tears. [27, 28]

For patient education information, see the Sprains and Strains Center, as well as Knee Injury, Knee Pain, and Magnetic Resonance Imaging (MRI).

The anterior cruciate ligament (ACL) is a dense fibrous band composed of collagen fibrils. It is approximately 3.5-3.8 cm long and 1 cm in transverse diameter. [29] The ligament originates from the posteromedial aspect of the lateral femoral condyle (well posterior to the longitudinal mid axis of the femur) in the intercondylar notch. It courses through the notch in an anterior, inferior, and medial direction. [2] The distal ligament diverges, forming a roughly 11-19 mm horseshoe-shaped tibial insertion footprint. It inserts well posterior on the tibia, averaging 23 mm posterior to the anterior edge. The ligament does not typically insert directly on the medial intercondylar eminence (medial tibial spine), instead inserting just anterior and lateral to it. [29, 30] The ACL is not as strong as the posterior cruciate ligament (PCL), and it is less strong at its femoral origin than at its tibial insertion. [29]

See the images below.

The ACL is organized into anteromedial and posterolateral bundles. The bundles are named for their locations relative to each other at their tibial insertion. [29, 31] The biomechanics of the bundles are complex and are under increasing investigation.  It is generally stated that the anteromedial bundle tightens with flexion of the knee and resists anterior translation of the tibia in flexion, while the bulkier and less isometric posterolateral bundle tightens with knee extension and resists hyperextension. [29]   The physiologic property in which different parts of the spriraled ACL are taut at different points in the normal range of motion is termed isometry.  Graft isometry is a stated goal of reconstructive surgery: the differing attachments and roles of the 2 bundles are the basis for the current intense investigational interest in double-bundle ACL reconstruction surgery. 

Interestingly, Smigielski et al dissected 111 cadavers and found that the ACL consistently demonstrates a flattened ribbon-like segment just 2mm from its femoral origin that is devoid of double bundle anatomy. [32]

Cadaver and clinical studies have shown the normal anteromedial and posterolateral bundles to be distinguishable in most patients at 3-Tesla. [33, 34, 35] Visualization of bundle anatomy is limited at 1.5 Tesla and low-field MRI imaging.

See the image below.

The ACL is an extrasynovial and intracapsular ligament. Bands of mesentery-like synovium, arising from the posterior intercondylar region of the tibia, surround the cruciate ligaments. [29] This feature accounts for fluid often seen anterior to the normal ACL (and posterior to the PCL) on MRI. The extrasynovial location also helps explain why hemarthrosis is often delayed in the setting of an acute ACL tear.

The primary blood supply to the ACL derives from arteries to the surrounding synovial membrane. These, in turn, derive from branches of the middle geniculate artery piercing the posterior capsule. [29] The central core of the ACL is relatively avascular. This helps explain the generally ineffective healing of ACL tears. Tibial nerve terminal branches innervate the ACL. [29] Sensory mechanoreceptors are present, and this causes loss of proprioception in ACL-injured patients that can be clinically significant.

Mechanisms of anterior cruciate ligament (ACL) injury are numerous. Alpine-skiing ACL injury studies have served to demonstrate the complexity of this subject: a welter of characteristic mechanisms of injury have been identified in skiers, including aggressive quadriceps contraction, boot-induced injuries, “phantom foot” injuries, hit-from-behind injuries, and various types of valgus, rotatory, and hyperextension injuries. ACL tear mechanisms in fact will be only superficially discussed in this article.

ACL tears occur with or without contact and with the knee in any position from flexed to fully extended. A well-known contact mechanism of injury is the valgus-abduction clip injury. [30] These injuries are frequent in football players and occur with a lateral blow to the partially flexed knee. Coexisting medial and lateral meniscal tears are common, as are medial collateral ligament (MCL) injuries.

Hyperextension or varus-hyperextension from an anterior blow (eg, injury from a motor vehicle accident or contact sports) is the second most common contact mechanism of ACL injury. The posterior cruciate ligament (PCL) and posterolateral-corner structures are also frequently injured. With more severe hyperextension, the knee may dislocate; the popliteal neurovascular bundle or peroneal nerve may be injured in this setting.

See the image below.

However, noncontact mechanisms account for the majority (70-80%) of ACL tears. [30, 36] The pivot-shift mechanism (see the images below) is most commonly implicated: the slightly flexed knee incurs a valgus load, with internal rotation of the tibia or external rotation of the femur. Some studies indicate that the initial loading of the ACL is actually due to anterior drawer translation of the lateral tibia (marked quadriceps loading implicated), with the pivot-shift rotation occurring microseconds later. [36]   These pivot-shift injuries often occur with rapid simultaneous deceleration and directional movements in skiers and football, basketball, and soccer players.  Again, associated meniscal tears and collateral ligament injuries are common (much less often, lateral patellar subluxation).  

See the image below.

Noncontact hyperextension, such as that occurring in a gymnast or cheerleader who misses a landing, is another mechanism of injury that often injures the ACL. [30]

The incidence of ACL tears in females is higher than that in males for each hour of participation in activities at risk. A relative risk of up to 10 times higher has been suggested; however, a review of the literature by Prodromos et al suggests a more modest 3.5 times greater risk (basketball being the sport with the greatest sex differential). [37, 38] Explanations for this increased susceptibility are under debate. [39] Lax joints, more common in females, appears to predispose patients to ACL injury. [40, 41]   Many other predisposing anatomic features common to both males and females are under investigation. 

Relevant history and physical examination findings should be provided to the MRI reader. Especially helpful is history regarding previous knee surgeries and dates of injuries. The authors have found it beneficial for technologists to place MRI markers at sites of pain and surgical scars.

Only basic guidance in performance of MRI of the knee is provided below.

Knee MRI protocols must be designed to yield diagnostic images of not only the anterior cruciate ligament (ACL),  but also the menisci, bones, articular cartilage, and other ligamentous structures of the knee. Furthermore, the requirements for optimal meniscus and cartilage imaging are more exacting than the requirements for diagnostic ACL imaging. As such, for the most part, a protocol that images the menisci and cartilage optimally also adequately demonstrates the ACL. This explains why most centers image patients in full knee extension, though the ACL is optimally evaluated with the knee in about 30° of flexion. Imaging in flexion complicates evaluation of the menisci and other knee structures. [42]

The minimal protocol requirements of ACL imaging include T2-weighted sequences (or proton-weighted fat-suppressed) in 2-3 orthogonal planes. [43, 44] Most centers perform at least one T1-weighted sequence in either the sagittal or coronal plane.

T2-weighted sequences are most important in diagnosing acute ACL injuries. [45, 46] This is due in part to confounding increased signal intensity seen in ligaments and tendons in short-echo time T1 and gradient-echo sequences. This, in turn, is related to internal degeneration, magic-angle artifact, and other factors. Fast spin-echo fat-saturation sequences (termed turbo spin-echo by some vendors) are faster and more sensitive to injury than conventional T2-weighted spin-echo images and have largely replaced these sequences.

Any of the 3 imaging planes may prove pivotal to interpretation in a given case (see the images below). The MRI reader should routinely inspect the ACL in all planes and become familiar with the range of normal and abnormal in each plane. Axial images in particular provide a cross-sectional perspective free of partial volume artifact with the intercondylar roof and are invaluable in evaluation of the proximal ACL. [43, 47, 48, 49]

Several methods for the prescription of sagittal images of the ACL by the MRI technologist have evolved over time. Early recommendations were to allow patients to naturally externally rotate their legs and then to prescribe longitudinal images perpendicular to the table. However, this method leads to suboptimal, inconsistent results.

The subsequent recommendation was to perform sagittal oblique slices 10-15° off a perpendicular to a bicondylar line tangent to the posterior margins of the medial and lateral femoral condyles on an axial scout image, thus aligning images closer to the long axis of the ACL.

Garner et al demonstrated that the true sagittal plane (perpendicular to the bicondylar line) is superior for evaluation of the ACL (Unpublished data, Mayo Clinic, Jacksonville, Fla. Presented at Society of Skeletal Radiology, March 2009). This also restores optimal meniscal evaluation. The authors have noted the same and recommend this simpler approach.

Most MRI vendors provide for a number of 3-dimensional thin-slice isotropic imaging options, including isotropic fast spin-echo sequences. These acquisitions allow equal high-resolution reformatting in any desired plane. Such data sets are now acquired routinely in the knee protocols of most modern imaging centers (including those of the authors). With an indeterminate ACL, the imager may sit at a workstation and post-process high-resolution ACL images in any desired plane. Further studies, however, are needed to determine the value added by these 3-dimensional isotropic data sets.

Other special problem-solving oblique ACL sequences have not found wide application but clearly may be helpful in equivocal cases. Katahira et al reported increased ACL diagnostic accuracy prescribing oblique coronal images parallel to the long axis of the ACL as prescribed off of an oblique sagittal image (the sagittal image was in turn prescribed off a coronal image). [50]   This is termed a “double-oblique” sequence.  Park et al reported improved diagnosis of single bundle tears on 3-T scanners with oblique coronal sequences prescribed off a sagittal image. [51]  Several other investigators have also reported improved diagnosis prescribing oblique imaging along the ACL long axis. [52, 53, 54, 55]  One of the authors listed above and this author favor oblique coronal problem-solving sequences over oblique sagittal sequences. 

See the images below.

In equivocal cases, the MRI reader may also try imaging the knee in mild flexion.  ACL imaging is improved,  owing in part to decreased partial voluming of the proximal ACL with the intercondylar roof. [42, 56]  See the image below. 

Kinematic imaging for the diagnosis of ACL tears has been proposed. [57]

MRI cannot be safely performed in some clinical settings, such as in patients with pacemakers. While reports are favorable regarding CT scanning (or CT arthrography) in the evaluation of the ACL, further studies are needed. [58] Limited data indicate that CT scanning may be reliable in confirmation of the negative ACL but less reliable in assessment of the torn ACL. [59]

Three-dimensional virtual CT scanning has been described. [60]

On sagittal images, the normal anterior cruciate ligament (ACL), as shown in the image below, appears as a solid band or as a striated band diverging slightly distally. Interestingly, while the ACL is known to be composed predominantly of anteromedial and posterolateral bands, as many as 4 distinct striations may be visible. [44] The ACL is usually ruler-straight; however, mild convex-inferior sagging may be evident in normal ACLs.

The ACL substance shows slightly higher signal than that of the adjacent posterior cruciate ligament (PCL), with low-to-intermediate intensity. The distal ACL further demonstrates relatively increased signal intensity,  owing in part to distal divergence of bands/striations. Data from one study confirmed that the increased internal signal intensity is the result of macroscopic (rather than histologic) features of the ACL, although in elderly patients, internal degeneration accounts for some of the observed increased signal intensity. [61]

On coronal images, a normal ACL (see the image below) is usually well seen, although the band (or bands) often appears much more attenuated and less bulky than in the sagittal plane. The lateral position of the ACL in the femoral intercondylar notch is apparent in the coronal plane; the PCL is seen medially. In normal ACLs, ample fat signal is seen in the notch surrounding the cruciate ligaments (see T1-weighted image in Anatomy).

In the axial plane, the proximal ACL is especially well seen (see the image below) and appears normally as an elliptical low-signal intensity band adjacent to the lateral wall of the upper intercondylar notch. It gradually moves away from the wall and splits into a horseshoe (fan-shaped) array of fascicles as it approaches its tibial insertion. [47] The distal ACL is difficult to critically evaluate on axial images.

Normal distinct anteromedial and posterolateral bands are identifiable in the majority of patients imaged at 3-Tesla field strength (94% of patients in a study by Adriaensen et al [35] ). The posterolateral band is so named because of its relatively posterolateral tibial insertion, and this serves to explain the more vertical appearance of this band on sagittal and coronal plane images.

It is not uncommon for the ACL to be suboptimally demonstrated in healthy knees in the sagittal plane. [44]   T1-weighted images are especially likely to demonstrate an ill-defined indeterminate ACL appearance. However, the absence of hemorrhage or edema in the expected location of the ACL, a normal appearance of the ACL in other planes, and the absence of secondary signs of ACL injury are almost always sufficient to confirm that the ACL is normal. [44] Smith et al noted that the ACL is highly likely intact when poorly visualized on either the T1- or T2-weighted sagittal sequence and normal in appearance on other sequences. [62]

Partial-volume superimposition of the inner aspect of the lateral femoral condyle on the proximal ACL may produce a pseudomass that mimics an acute ACL tear on sagittal images.

See the image below.

If section thicknesses of 4 mm or less are routinely used and if other imaging planes are correlated, this is not a diagnostic problem. [44]

 

Studies report variable 78-100% sensitivity and 68-100% specificity of MRI for the diagnosis of anterior cruciate ligament (ACL) tears. [13, 43, 45, 46, 63, 64, 65, 66, 67, 68] Accuracy of approximately 95%, however, has been reported in more recent studies, with the diagnosis of proximal, partial, or chronic tears accounting for many of the persistent errors in interpretation. Sensitivity is also significantly decreased if other major ligamentous injuries are present in the knee. [69]

Less data are available for children than for adults. Decreased accuracy of MRI has been reported in preadolescents, [70] but a study of patients aged 5-16 years demonstrated a sensitivity of 95% and a specificity of 88%. [16]

ACL accuracy has not been shown to be significantly improved with 3-Tesla imaging, despite demonstrably improved visualization of distinct anteromedial and posterolateral bands. [35, 71, 72]

Most ACL tears (about 70%) occur in the middle aspect of the ligament [29] ; 7-20% occur proximally near its origin. Only 3-10% occur distally at the tibial attachment. [44]

Primary signs of acute ACL tear (ie, MRI abnormalities of the ACL proper) allow for high accuracy in the diagnosis of ACL injury, even in the absence of secondary signs. [16, 46, 63, 66, 73, 74]

See the images below.

 

The primary signs of an ACL tear include nonvisualization, disruption of the substance of the ACL by abnormal increased signal intensity, abrupt angulation or a wavy appearance, and an abnormal ACL axis. The axis of the ACL is abnormal if it is clearly more horizontal than a line projected along the intercondylar roof (Blumensaat line) on sagittal images. The ACL axis can be quantitated (although the authors have not found this to be necessary). [75]

A common presentation of an acute ACL tear is nonvisualization of the ligament with replacement by an ill-defined cloud of focal edema and hemorrhage. A partial tear manifesting as enlargement of the ACL and increased internal signal intensity but with visible intact fascicles has been termed an interstitial tear (or delaminated tear). These appearances must be differentiated from mucoid degeneration of the intact ACL (discussed later in this article).

A torn or partially torn ACL stump may angle anteriorly into the anterior intercondylar notch, with or without nodule formation. This has been called the “bell-hammer sign,”  or the “preoperative cyclops syndrome ” (analagous to focal arthrofibrotic cyclops lesions developing anterior to ACL grafts). [76, 77]   (We will discuss this tear presentation further in the partial tear and chronic tear sections.)

Axial images should be reviewed as diligently as the sagittal and coronal images for primary signs of ACL tear. The elliptical hypointense band representing the proximal ACL may be attenuated, fragmented, completely or partially replaced by hemorrhage, or displaced away from the lateral wall of the intercondylar notch. [47]

See the images below.

MRI findings of an ACL tear apart from abnormalities of the ACL proper are termed secondary signs. The sensitivity of these signs is limited [63] ; therefore, the absence of secondary signs in no way excludes ACL disruption. Certain signs, however (discussed below), have greater than 80% specificity for ACL injury. As a consequence, they may allow for a fairly confident diagnosis of tear when primary signs are equivocal. [63, 65, 66, 78, 79, 80, 81, 82, 83, 84, 85, 86]

Secondary signs with high specificity for ACL injury include pivot-shift bone bruises/osteochondral fractures and Segond fractures.

Pivot-shift bone bruises and fractures

With a pivot-shift rotatory injury of the ACL, there is external rotation of the lateral femoral condyle relative to the fixed tibia. This shift allows the lateral femoral condyle to impact the posterolateral tibial plateau, frequently causing characteristic bone bruises of one or both bones. [46, 82, 84] The lateral femoral condyle bone bruise is usually near the anterior horn lateral meniscus but may be more posteriorly located if the injury occurs during flexion. The tibial bone bruise subtends the posterolateral corner of the tibia.

See the images below.

With more severe injury, osteochondral fractures may accompany these bone bruises. MRI demonstrates linear subchondral fracture lines or cortical contour flattening. Sagittal MRIs (and lateral radiographs) may reveal a “deep lateral femoral-notch sign” that manifests as an exaggerated (>1.5-mm-deep) condylopatellar notch of the lateral femoral condyle. [79, 87] Pivot-shift fractures of the posterolateral tibial plateau are easily seen on MRIs are but often occult on radiographs. These fractures manifest as subtle cortical impaction or as a posterior capsular bony avulsion fragment. [88]

Characteristic pivot-shift bone bruises (and osteochondral fractures) of the tibia or femur indicate a greater than 90% likelihood of ACL injury. [30] However, pivot-shift bone bruises can occur rarely without an associated ACL tear, usually in the pediatric or adolescent population. [89]

“Contrecoup” medial tibial bone bruises/impaction fractures may be seen with especially pronounced pivot-shift twisting injuries. These injuries involve the posteromedial tibial plateau at or near the semimembranosus tendon insertion.

See the images below.

Bone bruises were originally reported to persist on MRIs for about 6 weeks. [80] It is now clear, however, that bone bruises commonly remain visible on MRI studies 12-14 weeks after injury.

It is surmised that MRI-diagnosed bone bruises probably have prognostic significance by indicating an increased probability of underlying articular chondral injury and subsequent joint degeneration. [26, 90]

Anterior translocation of the tibia

Anterior translocation of the tibia is the MRI correlate to anterior drawer instability elicited on physical examination and, as such, indirectly suggests ACL incompetency. The radiologist should seek this finding on sagittal images through the middle of the lateral femoral condyle. If the tibia translocates anteriorly to the extent that the distance between vertical tangent lines through the posterior margins of the femur and tibia laterally exceeds 5 mm, acute or chronic ACL tear is likely. [78, 86] Milder degrees of anterior translocation are unreliable.

See the image below.

Abnormal tibial translocation is also suspected if a vertical line tangent to the posterior cortex of the tibial plateau courses through, or anterior to, the posterior horn meniscus (the “uncovered meniscus sign”). 

An unusually vertically oriented lateral collateral ligament (LCL), seen in its entirety on a single slice, is essentially another manifestation of anterior drawer displacement of the lateral tibia. The normal LCL is tilted off the coronal plane and thus requires review of multiple consecutive coronal images to visualize the ligament from origin to insertion. As a corollary of this, a verticalized single-slice LCL is a soft secondary sign of ACL compromise. [91]

See the image below.

Segond fracture: high association with ACL injury

A Segond fracture (see the images below) is a stereotypical fracture of the tibia that has a 75-100% association with ACL tear. [29] The Segond fracture is an elliptical, vertical, 3 X 10-mm bone fragment paralleling the lateral tibial cortex about 4 mm distal to the plateau. Segond fractures have historically been attributed to traction avulsion of the middle third of the meniscotibial capsular ligament; more recently, slips of the iliotibial band and lateral collateral ligament complex have been implicated. [92]

On MRIs, the Segond fracture fragment is often inconspicuous and easily overlooked. In fact, the MRI reader is often tipped off instead by an associated focal marrow edema-like signal focus of the adjacent lateral tibial plateau. The Segond fragment demonstrates a marrow-edema high T2-signal appearance in the acute setting; in the long term, it usually shows isointensity relative to marrow (or low signal related to osseous sclerosis) and may fuse to the underlying bone. [29, 93]

On plain films, a Segond fracture must be distinguished from a Gerdy tubercle bony avulsion anterolaterally (with iliotibial band traction); this fracture is optimally seen on a radiograph with external rotation. In contrast, a Segond fracture is best seen on a true anteroposterior radiograph (and is also readily shown on a tunnel view). [29, 94]

Fracture of the tibial spine: less reliably associated with ACL tear

The ACL does not actually insert on the anterior tibial spine; it inserts immediately lateral and anterior to it. Thus, tibial spine fractures can be seen in patients with a normal competent ACL; nevertheless, the possibility of an ACL tear (or ACL insufficiency) should be borne in mind when these fractures are detected. Tibial spine avulsion with ACL insufficiency or injury indicates a hyperextension mechanism in most cases. While relatively more common in the pediatric population, the majority of ACL tears in children are not associated with a tibial osseous avulsion. Only 5% of adults with traumatic ACL insufficiency have an associated tibial avulsion. Tibial spine fractures are often isolated in children, but they imply a high-force injury in adults and other internal derangements are usually present. [30, 95, 96, 97]

See the images below.

On MRI, tibial spine fracture fragments may be small and difficult to appreciate. The MRI reader must be alert for their presence, especially in MRI examinations in children.

See the image below.

Several tibial spine fracture classification systems have been proposed. [98] Treatment is somewhat controversial; however, surgery is often performed in the setting of displaced larger fractures.

The image interpreter should be alert for 5 fractures that are statistically associated with ACL injuries. Two of these fractures have a very high association with ACL tear: the Segond fracture and the deep-lateral femoral-notch sign fracture. Three other fractures have an intermediate probability of ACL injury: tibial spine avulsion fracture, fracture of the posterolateral corner of the tibia, and arcuate fibular head fracture (discussed below). As noted above, the MRI reader should be especially careful to search for a subtle Segond fracture (or adjacent associated focal marrow edema focus of the tibia) and tibial spine avulsions. These findings may be helpful in the setting of equivocal primary MRI signs of ACL injury. [87] CT correlation may be helpful in difficult cases.

Kissing anterior femoral and tibial bone bruises suggest a hyperextension injury. [99] Similarly, avulsion fractures of the proximal fibula (termed the arcuate sign) predict a possible hyperextension/varus injury. The LCL complex is usually torn, and the ACL was torn in 13 of 18 patients in one study. [100] Posterior cruciate ligament (PCL) tears are also often present in these hyperextension injuries. In severe cases, the knee frankly dislocates and popliteal neurovascular injuries should be sought on images. [101]

See the images below.

An arched redundant-appearing PCL is one of the least useful secondary signs of ACL injury. While this occurs commonly in ACL injuries with anterior translation of the tibia, similar appearances occur with hyperextended normal knees and with quadriceps dysfunction. [30, 80, 102]

See the image below.

Cadaveric studies have shown no normal synovial recesses in the triangular space inferior to the intersecting ACL and PCL as observed on sagittal images. Therefore, Lee et al hypothesized that fluid in this location may indirectly indicate abnormality of the cruciate ligaments, but this has not been confirmed in a clinical setting. [103] As noted previously, fluid-filled synovial recesses anterior and posterior to the ACL are a common finding in normal ACLs. Edema in the region of the ACL is an abnormal but nonspecific finding [85] ; other evidence is needed to make a definitive diagnosis of tear.

Partial tears of the ACL are common, accounting for 10-43% of all ACL tears [16, 22, 47, 104] and accounting for a higher percentage of ACL tears in the pediatric population. [105] The natural history and optimal treatment of these injuries is still being worked out. [22, 106] A tear involving less than 25% of the ACL arthroscopically has a favorable prognosis; a tear involving 0.5-0.75 of the ACL has a high probability of progressing to a complete tear. [22, 104, 106, 107] Overall, less than 50% of patients with an unoperated partial tear are able to return to their preinjury level of activity. [108]

On physical examination, partial tears often present with a normal or indeterminate Lachman test. [22, 109] In cadavers, laxity is absent on physical examination and arthrometric testing when only the anteromedial band of the ACL is transected.

See the images below.

While MRI is accurate in differentiating the normal from abnormal ACL, it is less reliable in the diagnosis of partial tears. [80, 106, 110]  

Van Dyck et al list 4 principal presentations of ACL partial tears on MRI images. [111] First, partial tears often resemble a complete tear in all respects on MRI images. [106] Overestimation of tear severity in this setting fortunately should have little effect on outcomes since most of these higher grade tears are thought to progress to full tear if the patient returns to previous activity.  It should be re-emphasized that secondary signs of ACL tear (eg, pivot-shift bone bruises) are common to both complete and the more pronounced partial tears and therefore cannot striclty differentiate partial from complete tears. [83, 74]

Second, partial-tear ACL appearances may resemble mucinous degeneration. The ligament is enlarged with straight, intact-appearing fibrils separated by intermediate-high signal. This represents a delaminating form of injury, less severe than transverse tears, and thus patients may be functional on clinical testing.

Third, the partial tear may appear normal on MRI images.  Knowing this, the possibility of an MRI-occult partial tear must be considered in the setting of a suggestive injury mechanism when there is laxity on clinical/ arthrometic testing or there are indirect signs of ACL injury on the MRI (such as pivot-shift bone bruises or anterior tibial translation).  

Fourth, partial tears may present as an isolated bundle tear. However several studies have shown that isolated bundle tears account for only a small percentage of tears that go to arthroscopy. [74, 112]  This helps explain why 3-Tesla imaging, despite improved visualization of bundle anatomy, continues to demonstrate limiited overall accuracy in diagnosing partial tears. [72, 111, 74, 112]  One may suggest a partial tear even when bundle anatomy is not distinct, when there appears to be partial-thickness abnormal increased signal thinnning the normal tendon,  or when there are primary signs of a tear on one slice while an adjacent section shows a normal taut ACL. [106, 3, 113]  Clearly, however, such findings have limited specificity for tear.  This is due to multiple confounding factors, including intraligamentous degenerative increased signal and partial volume artifacts.

As previously discussed, a partially or completely torn ACL may form a stump that angles anteriorly into the anterior intercondylar notch region (the so called “bell-hammer sign” or “preoperative cyclops syndrome”). [76, 77]   Lefevre et al have pointed out that while this is a an uncommon tear presentation,  it may serve as a tipoff that a partial tear is present in problem diagnostic settings.  This sign manifests as either (1) an anteriorly angled ACL stump or (2)  a heterogeneous variable-signal nodule projecting anteriorly from the ACL. Histologic evaluation of the nodules has revealed disorganized ACL fibers,  fibrosis, inflammation, and hemorrhage, mirroring the histology of post-graft cyclops lesions; as in post-graft patients with arthrofibrosis, these patients usually have restricted extension range of motion.

It is clear from the discussion above that MRI adds some value in the evaluation and management of partial tears, and positive MRI findings should not be ignored, even in the setting of a negative Lachman test. In most cases, the MRI reader should at least be able to classify MRI findings into either a complete versus high-grade tear category (high risk) or a normal versus low-grade tear category (lower risk). [47, 48, 69, 3, 114] Additional problem-solving oblique coronal sequences, [51]  isotropic voxel imaging, or flexed-position MRI sequences may be helpful.

Treatment recommendations for patients with partial ACL tears are evolving. Factors favoring conservative treatment include advanced age, a normal or near-normal Lachman result, low athletic demands, and less than 50% involvement of the ACL fibers on arthroscopy. Most young and highly active patients, patients with a clearly abnormal Lachman result, and patients with greater than 50% or posterolateral band involvement on arthroscopy are best treated with ACL reconstruction. [4]

The MRI reader not uncommonly encounters nonacute anterior cruciate ligament (ACL) tears. These injuries are often associated with meniscal tears and secondary osteoarthritis.

MRI signs of chronic ACL tear are similar to those of acute ACL injury, except that bone bruises and edema around the knee are no longer visible as clues for the image reader that a tear is present. [85, 115]   In addition, there are several appearances unique to the chronic phase; for example, there may be an  “empty notch” sign with an absent ACL and a pristine fat signal evident in the lateral intercondylar notch. [44]

See the images below.

Secondly, as discussed earlier, a chronically torn ACL stump may angle anteriorly and enlarge into a nodule, the “pseudo-cyclops” appearance. Thirdly, the torn stump may flop posteriorly and attach to the posterior cruciate ligament (PCL). [30] The authors, however, have noted that the PCL attachment is most often an endoscopic observation and is less frequently appreciated on MRI, even in retrospect. These patients may have a clinical endpoint of anterior translation of the tibia with Lachman testing, resulting in a false-negative clinical examination.

The chronic nondisplaced ACL tear unfortunately may appear entirely normal, presumably because hypointense mature collagenous scarring cannot be distinguished from normal collagenous hypointense ligament. [85, 5]  The MRI reader must be especially diligent in the nonacute injury setting to avoid underdiagnosis. T1 sequences are more frequently informative in these patients and should be inspected diligently. Problem-solving additional MRI sequences or clinical correlation may be pivotal in diagnosis.

Mucoid degeneration of the ACL can mimic a delaminating ACL tear. [116, 117] The etiology of this entity is uncertain, but it may lie along a continuum of senescent degeneration of the ligament. [117] It is increasingly evident to this author and others that mucoid degeneration of the ACL is a fairly common entity. [118]

See the image below.

Reported patients are usually older than 30 years. Patients may be asymptomatic, but they frequently have pain and limited flexion of the knee. The knee is stable, with a negative Lachman test result.

On arthroscopy, the ACL is enlarged and often impinges on the intercondylar notch sidewalls or roof. Histologic examination of the ligament demonstrates extensive, patchy, yellow, internal deposits, which represent a mixture of fibrous elements and mucoid degeneration.

Treatment has consisted of mainly meticulous piece-by-piece debulking of the yellowish material. Some fascicles of the ACL may be sacrificed in this procedure. Notchplasty may also be performed to reduce ACL-notch impingement.

MRI appearances are characteristic. The ACL is enlarged with diffusely increased non–fluid-like increased signal internally that splays apart intact ACL fascicles. The splayed linear ACL fascicles have a “celery-stalk” appearance. As noted previously, the reader must also consider a delaminating tear with this appearance. A nontraumatic history, a negative Lachman test, and a lack of secondary signs of an ACL tear should suggest the correct diagnosis. [30, 116, 117, 119, 120, 121]

Intraligamentous and extraligamentous ganglion cysts of the ACL are a related but distinct entity. The extraligamentous cysts are extremely common but do not present a diagnostic problem. These appear as well-defined, lobular, often septated cysts immediately adjacent to the ACL. These cysts are usually asymptomatic incidental findings, although a variety of symptoms have been reported. The smaller cysts may be difficult to differentiate from normal synovial recesses. [119]

Ganglion cysts in the substance of the ACL are less common but have been reported in all age groups. [122, 123, 124, 125, 126]

On MRI, ganglion cysts appear as fusiform well-defined cysts oriented along the long axis of the substance of an otherwise normal-appearing ACL. When the cysts are small, this appearance may be mistaken for that of a partial ACL tear, [123] but differentiation is usually not difficult.

See the image below.

Several authors have described ACL ganglion cysts that developed in young patients after trauma. [122, 127] As in diffuse mucoid degeneration of the ACL described above, the knee is stable with a negative Lachman result. However, symptoms may be clinically significant, and patients often benefit from arthroscopic probing with release of the mucinous material, with or without partial debridement. [29, 119]

Ganglion cysts of the ACL can be difficult to appreciate on standard arthroscopy. Therefore, diagnosis may depend on MRI; the MRI reader who recognizes the abnormality may alert the arthroscopist to probe the ACL or add a posterior portal approach. [117, 119, 120]

The ACL may be congenitally absent or hypoplastic. This usually occurs in association with intercondylar notch osseous stenosis and/or local or distant bone dysplasias, but rarely may be an isolated finding.  Most patients are asymptomatic (despite physical exam laxity) until an injury disturbs knee homeostasis. [128]   [129]

Calpur et al reported 2 patients with a markedly widened deltoid (triangular) distal ACL at the tibial insertion. [130] Symptomatic impingement of the intercondylar-notch structures was reported, and successful trimming of the distal ACL (ligamentoplasty) was performed in both patients.

The goal of this article is to educate the MRI reader in the evaluation of the normal and abnormal native anterior cruciate ligament (ACL). To this end, several points merit re-emphasis. 

One must become familiar with normal and abnormal appearances of the ACL in all planes. On sagittal images, the MRI reader should critically evaluate the ACL axis relative to the intercondylar roof. The proximal and distal aspects of the ACL should also be carefully evaluated, as tears or osseous avulsions may be readily overlooked in these locations. Axial sequences are especially useful in evaluating the proximal ACL. One should be alert for the secondary signs of ACL tear, including the often-subtle MRI findings of Segond fractures.

One should be aware of the lower accuracy of MRI for partial tears. Interstitial tears may rarely present with an appearance similar to mucinous degeneration of the ACL. Anteriorly angled ACL fibers, the “Bell-Hammer” or pseudo-cyclops appearance, may uncommonly be the only tipoff of a partial tear (or chronic tear). Chronic ACL tears are also apt to be missed. Subtle flattening of the ACL axis or slight angulation of the ligament may be the only sign of a chronic tear. Chronic tears may also present with an “empty notch sign.”

Regarding generation of images, it is now recommended that  sagittal images be obtained in the true orthogonal plane, rather than performing obliqued imaging.  In equivocal tear cases, one may perform an additional problem-solving sequence. Often helpful is the oblique coronal sequence prescribed along the long axis of the ligament on a sagittal image. Flexed-knee sagittal imaging may show the proximal ligament to advantage. 

Finally, satisfaction-of-search errors should be avoided. When the ACL is torn, the interpreter should look diligently for other internal derangements, especially peripheral meniscal tears and lateral collateral ligament (LCL) injuries.

There is much room for progress in MRI of the ACL. Fortunately, faster and more informative MRI examinations can be anticipated as a result of continued technological advances in instrumentation, software, and contrast agents. New types of sequences are emerging every year, and dynamic imaging during range of motion may become practical and useful as a supplement to the current static imaging.

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Anton M Allen, MD Assistant Residency Program Director, Associate Professor, Department of Radiology, University of Tennessee Medical Center at Knoxville

Anton M Allen, MD is a member of the following medical societies: American College of Radiology, American Roentgen Ray Society, Radiological Society of North America, Society of Skeletal Radiology

Disclosure: Nothing to disclose.

Ryan William Owen, MD Resident Physician, Department of Radiology, University of Tennessee Medical Center at Knoxville

Ryan William Owen, MD is a member of the following medical societies: American College of Radiology, American Medical Association, American Roentgen Ray Society, Radiological Society of North America, South Carolina Medical Association, Southern Medical Association, Tennessee Medical Association

Disclosure: Nothing to disclose.

Javier Beltran, MD Chair, Department of Radiology, Maimonides Medical Center

Disclosure: Nothing to disclose.

Felix S Chew, MD, MBA, MEd Professor, Department of Radiology, Vice Chairman for Academic Innovation, Section Head of Musculoskeletal Radiology, University of Washington School of Medicine

Felix S Chew, MD, MBA, MEd is a member of the following medical societies: American Roentgen Ray Society, Association of University Radiologists, Radiological Society of North America

Disclosure: Nothing to disclose.

David S Levey, MD Musculoskeletal and Neurospinal Forensic Radiologist; President, David S Levey, MD, PA, San Antonio, Texas

David S Levey, MD is a member of the following medical societies: American Roentgen Ray Society, Bexar County Medical Society, Forensic Expert Witness Association, International Society of Forensic Radiology and Imaging, International Society of Radiology, Technical Advisory Service for Attorneys, Texas Medical Association

Disclosure: Nothing to disclose.

Alan W Horn, MD Consulting Staff, Department of Radiology, Bryan Radiology Associates

Alan W Horn, MD is a member of the following medical societies: American Medical Association and Radiological Society of North America

Disclosure: Nothing to disclose.

Timothy N Ozburn, MD Resident Physician, Department of Radiology, University of Tennessee Medical Center at Knoxville

Timothy N Ozburn, MD is a member of the following medical societies: Radiological Society of North America

Disclosure: Nothing to disclose.

MRI for Anterior Cruciate Ligament Injury

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