Middle-Third Forearm Fractures
For descriptive purposes, as well as for operative considerations, forearm fractures are classified by location, being categorized as proximal-third, middle-third, or distal-third fractures. The middle third of the radius stretches from the radial bow to the beginning of diaphyseal straightening. The ulna is relatively straight and can be divided by using longitudinal dimensions alone. (See also Forearm Fractures, Distal-Third Forearm Fractures, and Forearm Fractures in Emergency Medicine, as well as Galeazzi Fracture and Monteggia Fracture.)
Unlike fractures in infants and children, fractures of the adult forearm are unstable. Nonunions and malunions of both-bone forearm fractures are functionally and cosmetically limiting, with midshaft radius or ulna angulation substantially impeding forearm rotation. 
Treatment objectives for both-bone forearm fractures have remained relatively constant, with early extremity range of motion (ROM). To understand the management of forearm fractures, the idea of the forearm axis was created, combining the function and anatomy of the wrist, forearm, and elbow. The coordinated, independent function of the wrist, forearm, and elbow is necessary to place and orient the hand in space. Injury to any of these components can result in a significant deficit. The three basic stabilizers of the forearm are as follows:
The ulna is the stable unit about which the radius rotates. Force transmission is initiated at the wrist (distal radioulnar joint) level and is translated longitudinally between the radius, ulna, and interosseous membrane, through the forearm axis, and to the elbow.
An applied compressive load travels along the proximal radius, transferring tension forces to the interosseous membrane, which transfers a compressive load to the proximal ulna.  This mechanism accounts for the inequality in the contact forces between the radius and the ulna at the wrist and elbow. Fracture or dislocation of the forearm lead to disruption of this longitudinal relation and affects wrist, forearm, and elbow function.
Middle-third, or diaphyseal, forearm fractures commonly result from a direct blow or a fall from a height. Other causes include gunshot wounds, motor vehicle accidents, and pathologic bone fractures.
According to the AO (Arbeitsgemeinschaft für Osteosynthesefragen [Association for Osteosynthesis]) documentation center, forearm fractures accounted for 10-14% of all fractures between 1980 and 1996.
Since the introduction of compression plating, the goal of forearm fracture treatment has been fracture union and the return of normal function.
In 1975, Anderson et al reported their experience with 4.5-mm compression plating of forearm fractures and noted a 97.9% rate of union for the radius and a 96.3% rate of union for the ulna.  Time to fracture union averaged 7.4 weeks and 7.3 weeks for radial and ulnar fractures, respectively. Additionally, the authors reported a 2.9% infection and nonunion rate. In this report, they developed a functional outcome evaluation scale, as follows:
Using this scale, the authors recorded a combined 85% rate of excellent and satisfactory results for the treatment of 330 acute fractures in 244 patients. 
In 1989, Chapman et al reported their results from the treatment of 129 diaphyseal fractures of the radius and/or ulna using standard 3.5-mm compression plates.  They recorded a fracture union rate of 98%, an infection rate of 2.3%, and a 92% rate of excellent or satisfactory results using the Anderson forearm evaluation scale.
Similar results have been reported by a number of other authors. Complications in most series were thought to be associated with errors in judgment, with technique, and with a lack of attention to detail. Immediate open reduction with internal fixation (ORIF) is recommended for all open both-bone middle-third forearm fractures. Results have reportedly been excellent or good in 85% of fractures, with an infection rate of 4% and a nonunion rate of 7%.
Prasarn et al described a protocol for repair of infected nonunions of diaphyseal forearm fractures, consisting of aggressive surgical debridement, definitive fixation after 7-14 days, tricortical iliac crest bond grafting for segmental defects, leaving wounds open to heal by secondary intention, 6 weeks of culture-specific intravenous (IV) antibiotics, and early active ROM exercises.  Of 15 patients, 12 had at least 50º of supination/pronation and 30-130º of flexion/extension arc. Aside from one failure (46 months to resolution), average time to union was 13.2 weeks.
Guitton et al described 13 pediatric patients with an isolated diaphyseal fracture of the radius, of whom 10 were treated with manipulative reduction and immobilization with an above-elbow cast and three were treated with plate-and-screw fixation.  All 13 patients, with at least 1-year follow-up, regained full elbow flexion and extension and full forearm rotation. According to the authors, treatment of isolated diaphyseal radius fractures in skeletally immature patients is associated with a low complication rate and excellent functional outcome.
Teoh et al compared the differences in radiographic and functional outcomes in children with unstable both-bone diaphyseal forearm fractures after treatment with either intramedullary (IM) fixation or plate fixation with screws.  Plate fixation and IM nailing both resulted in good or excellent functional and radiologic outcomes.
For the patients with plates, radiographs showed complete healing, with reconstitution of the radial bow.  Three patients in the IM group did not regain their natural radial bow. No nonunion or malunion was observed, and there were no significant differences in the loss of forearm motion and grip strength between the two groups. Osteomyelitis was more likely to occur in the IM fixation group, and ulnar nerve palsy occurred in the plate-fixation group.
Du et al conducted a study to compare outcomes of single and double elastic stable intramedullary nailing (ESIN) in the treatment of pediatric both-bone forearm fractures.  They retrospectively analyzed 49 children with both-bone forearm fractures treated with ESIN, of whom 24 were treated with single-ESIN (S-ESIN) to fixate the radius only and 25 with double-ESIN (D-ESIN) to fixate both the radius and ulna.
In this study, duration of surgery, times of fluoroscopy, and cost of hospitalization were significantly lower in the S-ESIN group than in the D-ESIN group.  The average period of castoff was longer in the former, and the incidence of delayed union of the ulna was significantly higher in the latter. Mean angulation deformity of the ulna was significantly larger in the S-ESIN group than in the D-ESIN group, though both were acceptable (<10°), and there was no difference in loss of forearm motion or complication rates between the two groups.
Richard MJ, Ruch DS, Aldridge JM 3rd. Malunions and nonunions of the forearm. Hand Clin. 2007 May. 23(2):235-43, vii. [Medline].
Birkbeck DP, Failla JM, Hoshaw SJ. The interosseous membrane affects load distribution in the forearm. J Hand Surg [Am]. 1997 Nov. 22(6):975-80. [Medline].
Anderson LD, Sisk D, Tooms RE. Compression-plate fixation in acute diaphyseal fractures of the radius and ulna. J Bone Joint Surg Am. 1975 Apr. 57(3):287. [Medline].
Chapman MW, Gordon JE, Zissimos AG. Compression-plate fixation of acute fractures of the diaphyses of the radius and ulna. J Bone Joint Surg Am. 1989 Feb. 71(2):159-69. [Medline].
Prasarn ML, Ouellette EA, Miller DR. Infected nonunions of diaphyseal fractures of the forearm. Arch Orthop Trauma Surg. 2009 Dec 10. [Medline].
Guitton TG, Van Dijk NC, Raaymakers EL, Ring D. Isolated Diaphyseal Fractures of the Radius in Skeletally Immature Patients. Hand (N Y). 2009 Oct 27. [Medline].
Teoh KH, Chee YH, Shortt N, Wilkinson G, Porter DE. An age- and sex-matched comparative study on both-bone diaphyseal paediatric forearm fracture. J Child Orthop. 2009 Oct. 3(5):367-73. [Medline]. [Full Text].
Du SH, Feng YZ, Huang YX, Guo XS, Xia DD. Comparison of Pediatric Forearm Fracture Fixation Between Single- and Double-Elastic Stable Intramedullary Nailing. Am J Ther. 2014 Jan 9. [Medline].
Casey PJ, Moed BR. Fractures of the forearm complicated by palsy of the anterior interosseous nerve caused by a constrictive dressing. A report of four cases. J Bone Joint Surg Am. 1997 Jan. 79(1):122-4. [Medline].
Schemitsch EH, Richards RR. The effect of malunion on functional outcome after plate fixation of fractures of both bones of the forearm in adults. J Bone Joint Surg Am. 1992 Aug. 74(7):1068-78. [Medline].
Moed BR, Kellam JF, Foster RJ. Immediate internal fixation of open fractures of the diaphysis of the forearm. J Bone Joint Surg Am. 1986 Sep. 68(7):1008-17. [Medline].
Boero S, Michelis MB, Calevo MG, et al. Multiple forearm diaphyseal fracture: reduction and plaster cast control at the end of growth. Int Orthop. 2007 Dec. 31(6):807-10. [Medline].
Garg NK, Ballal MS, Malek IA, Webster RA, Bruce CE. Use of elastic stable intramedullary nailing for treating unstable forearm fractures in children. J Trauma. 2008 Jul. 65(1):109-15. [Medline].
Mantout JP, Metaizeau JP, Ligier JN, et al. Embrochage centro-medullaire des fractures des deax os de l’avant-bras chez l’enfant. Technique. Indications. Ann Med Nancy. 1984. 23:149-51.
Weinberg AM, Amerstorfer F, Fischerauer EE, Pearce S, Schmidt B. Paediatric diaphyseal forearm refractures after greenstick fractures: operative management with ESIN. Injury. 2009 Apr. 40(4):414-7. [Medline].
Majed A, Baco AM. Nancy nail versus intramedullary-wire fixation of paediatric forearm fractures. J Pediatr Orthop B. 2007 Mar. 16(2):129-32. [Medline].
Schuind F, Andrianne Y, Burny F. Treatment of forearm fractures by Hoffman external fixation. A study of 93 patients. Clin Orthop Relat Res. 1991 May. (266):197-204. [Medline].
Bowman EN, Mehlman CT, Lindsell CJ, Tamai J. Nonoperative treatment of both-bone forearm shaft fractures in children: predictors of early radiographic failure. J Pediatr Orthop. 2011 Jan-Feb. 31(1):23-32. [Medline]. [Full Text].
Hong G, Cong-Feng L, Hui-Peng S, et al. Treatment of diaphyseal forearm nonunions with interlocking intramedullary nails. Clin Orthop Relat Res. 2006 Sep. 450:186-92. [Medline].
Visna P, Beitl E, Pilný J, Cizmár I, Vlcek M, Kalvach J, et al. Interlocking nailing of forearm fractures. Acta Chir Belg. 2008 May-Jun. 108(3):333-8. [Medline].
Lee YH, Lee SK, Chung MS, Baek GH, Gong HS, Kim KH. Interlocking contoured intramedullary nail fixation for selected diaphyseal fractures of the forearm in adults. J Bone Joint Surg Am. 2008 Sep. 90(9):1891-8. [Medline].
Zhang XF, Huang JW, Mao HX, Chen WB, Luo Y. Adult diaphyseal both-bone forearm fractures: A clinical and biomechanical comparison of four different fixations. Orthop Traumatol Surg Res. 2016 May. 102 (3):319-25. [Medline].
Cai L, Wang J, Du S, Zhu S, Wang T, Lu D, et al. Comparison of Hybrid Fixation to Dual Plating for Both-Bone Forearm Fractures in Older Children. Am J Ther. 2015 Feb 26. [Medline].
McLean JM, Stevenson AW, Samson A, Watts AC, Daneshvar P, Constant CR. A Pronator Teres-sparing Volar Approach for Osteosynthesis of Midshaft Diaphyseal Radius Fractures. Tech Hand Up Extrem Surg. 2015 Dec. 19 (4):138-42. [Medline].
Yaghoobi S, Seddighi M, Yazdi Z, Ghafouri R, Khezri MB. Comparison of Postoperative Analgesic Effect of Dexamethasone and Fentanyl Added to Lidocaine through Axillary Block in Forearm Fracture. Pain Res Treat. 2013. 2013:761583. [Medline]. [Full Text].
Sinikumpu JJ, Lautamo A, Pokka T, Serlo W. Complications and radiographic outcome of children’s both-bone diaphyseal forearm fractures after invasive and non-invasive treatment. Injury. 2012 Sep 14. [Medline].
Ayllon-Garcia A, Davies AW, Deliss L. Radio-ulnar synostosis following external fixation. J Hand Surg [Br]. 1993 Oct. 18(5):592-4. [Medline].
Bednar DA, Grandwilewski W. Complications of forearm-plate removal. Can J Surg. 1992 Aug. 35(4):428-31. [Medline].
Janos P Ertl, MD Assistant Professor, Department of Orthopedic Surgery, Indiana University School of Medicine; Chief of Orthopedic Surgery, Wishard Hospital; Chief, Sports Medicine and Arthroscopy, Indiana University School of Medicine
Janos P Ertl, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Orthopaedic Association, Hungarian Medical Association of America, Sierra Sacramento Valley Medical Society
Disclosure: Nothing to disclose.
William J Brackett, MD Research Assistant, Department of Orthopedic Surgery, Indiana University School of Medicine
Disclosure: Nothing to disclose.
Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference
Disclosure: Received salary from Medscape for employment. for: Medscape.
Robert J Nowinski, DO Clinical Assistant Professor of Orthopaedic Surgery, Ohio State University College of Medicine and Public Health, Ohio University College of Osteopathic Medicine; Private Practice, Orthopedic and Neurological Consultants, Inc, Columbus, Ohio
Robert J Nowinski, DO is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Medical Association, Ohio State Medical Association, Ohio Osteopathic Association, American College of Osteopathic Surgeons, American Osteopathic Association
Disclosure: Received grant/research funds from Tornier for other; Received honoraria from Tornier for speaking and teaching.
Harris Gellman, MD Consulting Surgeon, Broward Hand Center; Voluntary Clinical Professor of Orthopedic Surgery and Plastic Surgery, Departments of Orthopedic Surgery and Surgery, University of Miami, Leonard M Miller School of Medicine; Clinical Professor of Surgery, Nova Southeastern School of Medicine
Harris Gellman, MD is a member of the following medical societies: American Academy of Medical Acupuncture, American Academy of Orthopaedic Surgeons, American Orthopaedic Association, American Society for Surgery of the Hand, Arkansas Medical Society, Florida Medical Association, Florida Orthopaedic Society
Disclosure: Nothing to disclose.
Peter M Murray, MD Professor and Chair, Department of Orthopedic Surgery, Mayo Clinic College of Medicine; Director of Education, Mayo Foundation for Medical Education and Research, Jacksonville; Consultant, Department of Orthopedic Surgery, Mayo Clinic, Jacksonville; Consulting Staff, Nemours Children’s Clinic and Wolfson’s Children’s Hospital
Peter M Murray, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Orthopaedic Association, American Society for Reconstructive Microsurgery, Orthopaedic Research Society, Society of Military Orthopaedic Surgeons, American Association for Hand Surgery, American Society for Surgery of the Hand, Florida Medical Association
Disclosure: Nothing to disclose.
Middle-Third Forearm Fractures
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