Mesenteric and Omental Cysts in Children

Mesenteric and Omental Cysts in Children

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In 1907, the Italian anatomist Benevieni first reported a mesenteric cyst following an autopsy on an 8-year-old girl. [1] In 1842, von Rokitansky described a chylous mesenteric cyst. [2] Gairdner published the first report of an omental cyst in 1852. [3] Tillaux performed the first successful surgery for a cystic mass in the mesentery in 1880. [4]

Mesenteric cysts most commonly occur in the small-bowel mesentery on the mesenteric side of the bowel. They can often be shelled out from between the leaves of the mesentery with care taken to avoid damage to the mesenteric vessels, [5] or they may require concomitant bowel resection in order to ensure that the blood supply to the bowel is not compromised. [6] In a series from Egleston Children’s Hospital in Atlanta, one third of patients required intestinal resection along with resection of the mesenteric cysts. [7] Omental cysts can always be removed without resecting the adjacent transverse colon or the stomach. [5, 6]

No medical therapy is available. In children with mesenteric or omental cysts, the most common indication for surgical intervention is the presence of an abdominal mass with or without signs of intestinal obstruction.

Mesenteric and omental cysts can be either simple or multiple and either unilocular or multilocular, and they may contain hemorrhagic, serous, chylous, or infected fluid. [7] The fluid is serous in ileal and colonic cysts and is chylous in jejunal cysts. [8, 9] They can range in size from a few millimeters to 40 cm in diameter. (See the images below.)

As proposed by Gross, mesenteric and omental cysts are thought to represent benign proliferations of ectopic lymphatics that lack communication with the normal lymphatic system. [10, 11, 12] Cysts are thought to arise from lymphatic spaces associated with the embryonic retroperitoneal lymph sac; this makes them analogous to cystic hygromas, which arise in the neck in association with the jugular lymph sac. [13]

Another proposed etiology is lymphatic obstruction [5] ; however, experimental occlusion of lymphatic channels in animals does not produce mesenteric or omental cysts because of the rich collaterals in the lymphatic system, which sheds doubt on this particular theory. [14, 11, 13] Other etiologic theories include the following [7] :

Another variation includes chylous mesenteric cysts, which have a slight male to female preponderance of 1.4:1; presentation is usually in the fourth decade of life. [15] Primary mesenteric hydatid cysts have also been reported; these are extremely rare and present with chronic lower abdominal pain. [16]

Mesenteric cysts have been reported in association with Costello syndrome, which consists of short stature, redundant skin of the neck, palms, soles, and fingers, curly hair, papillomata around the mouth and nares, and mental retardation. [17]

Mesenteric cysts can occur anywhere in the mesentery of the gastrointestinal (GI) tract from the duodenum to the rectum, and they may extend from the base of the mesentery into the retroperitoneum. [7, 14] In a series of 162 patients, 60% of mesenteric cysts occurred in the small-bowel mesentery, 24% in the large-bowel mesentery, and 14.5% in the retroperitoneum. They most commonly occur in the ileal mesentery of the small bowel or the sigmoid mesentery of the colon. [18]

Omental cysts are confined to the lesser or greater omentum. [6] Congenital omental cysts that present as abdominal distention have been reported. [19] Omental cysts may be a result of dermoid cysts [20] or teratomas. [21]

Mesenteric and omental cysts are rare; the incidence is about 1 per 140,000 general hospital admissions and about 1 per 20,000 pediatric hospital admissions. [18, 14, 8] In a study from Egleston Children’s Hospital at Emory University from 1965 to 1994, 14 patients were treated for mesenteric or omental cysts, which represents a prevalence of about 1 case per 11,250 admissions. [7]

Approximately one third of cases occur in children younger than 15 years. [10, 22, 9] The mean age of children affected is 4.9 years. [10, 9, 23, 6, 24, 25, 26] Mesenteric cysts are 4.5 times more common than omental cysts. [27]

Overall results in pediatric patients are favorable. The recurrence rate ranges from 0% to 13.6%, [10, 9, 24, 25, 27] averaging about 6.1% in a series of 162 adults and children. [18] Most recurrences occur in patients with retroperitoneal cysts or those who had only a partial excision. [18, 24, 25, 27]

Essentially, no mortality is associated with mesenteric or omental cysts in children; only one pediatric death has been reported since 1950. [28] In a series from Egleston Children’s Hospital in Atlanta, no major postoperative complications, recurrences, or deaths occurred. [7]

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Amulya K Saxena, MD, PhD Consultant Pediatric Surgeon, Department of Pediatric Surgery, Chelsea Children’s Hospital, Chelsea and Westminster Healthcare NHS Fdn Trust, Imperial College London, UK

Amulya K Saxena, MD, PhD is a member of the following medical societies: International Pediatric Endosurgery Group, British Association of Paediatric Surgeons, European Paediatric Surgeons’ Association, German Society of Surgery, German Association of Pediatric Surgeons, Tissue Engineering and Regenerative Medicine International Society, Austrian Society for Pediatric and Adolescent Surgery

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Deborah F Billmire, MD Associate Professor, Department of Surgery, Indiana University Medical Center

Deborah F Billmire, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Pediatrics, American College of Surgeons, American Pediatric Surgical Association, Phi Beta Kappa, Society of Critical Care Medicine

Disclosure: Nothing to disclose.

Harsh Grewal, MD, FACS, FAAP Professor of Surgery and Pediatrics, Drexel University College of Medicine; Medical Director, Trauma Program and Attending Surgeon, St Christopher’s Hospital for Children

Harsh Grewal, MD, FACS, FAAP is a member of the following medical societies: American Academy of Pediatrics, American College of Surgeons, American Pediatric Surgical Association, Association for Surgical Education, Children’s Oncology Group, Eastern Association for the Surgery of Trauma, International Pediatric Endosurgery Group, Society of American Gastrointestinal and Endoscopic Surgeons, Society of Laparoendoscopic Surgeons, Southwestern Surgical Congress

Disclosure: Nothing to disclose.

Kurt D Newman, MD 

Kurt D Newman, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Surgeons, American Pediatric Surgical Association, Society of Surgical Oncology

Disclosure: Nothing to disclose.

Mesenteric and Omental Cysts in Children

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