Osteoblastoma is a rare primary neoplasm of bone, categorized as a benign bone tumor that is closely related to osteoid osteoma. It is a bone-forming lesion that may be found within the cortex, medullary canal, or periosteal tissues; multicentric foci within a single bone have also been described. There is a slight predominance of metaphyseal over diaphyseal locations.  Osteoblastoma differs from osteoid osteoma in its ability to grow larger than 2.0 cm in diameter and its aggressive behavior in bone. [2, 3, 4, 5, 6, 7, 8]
In his original description of osteoblastoma, Lichtenstein termed the lesion an “osteogenic fibroma of bone.” [9, 10] In 1954, Dahlin and Johnson reported 11 aggressive but benign tumors that appeared to originate within bone and were frequently difficult for the inexperienced pathologist to differentiate from malignancy.  They chose to call the tumor a giant osteoid osteoma for its histologic similarity to osteoid osteoma. The current and accepted name, osteoblastoma, was coined by Lichtenstein and Jaffe in their independent and more detailed reports of this neoplasm. [9, 12]
The clinical course of osteoblastoma often makes diagnosis difficult. The tumor may have a slow indolent course or display characteristics that are confused with malignancy, especially if it has an aneurysmal bone cyst component. Other diagnoses that share similar clinical, radiographic, and histologic features with conventional osteoblastoma include osteoid osteoma. Osteoblastomas may also have features that mimic malignant tumors, which often make it difficult for inexperienced surgical oncologists and pathologists to diagnose. Osteoblastoma is about 20 times less common than osteosarcoma is. [2, 13, 14, 15, 16, 17]
Osteoblastoma commonly affects the vertebral column, with approximately 30% of these lesions arising within the posterior elements of the spine. The vertebral body has been reported as the primary origin of these neoplasms in some reports, but these locations may be due to the failure to clearly identify the epicenter of the neoplasms (see the images below). Equally common locations (30%) are the long bones of the appendicular skeleton, typically the femur and the tibia, as is the case with all benign and malignant bony neoplasms.
Other documented locations of osteoblastoma include the pelvic bones, the small bones of the hands and feet, the skull/facial bones, the clavicle, the scapula, and the ribs. Osteoblastoma also arises in the talus more frequently than other benign tumors do (see the image below). [18, 19, 20, 21, 22]
Associated aneurysmal bone cysts (see the image below) may be seen with as many as 10% of osteoblastomas, imparting to these lesions much more aggressive and alarming characteristics.
Regardless of where osteoblastomas originate within the musculoskeletal system, they are composed of numerous osteoblasts that produce osteoid and woven bone. When the primary site is within cortical bone, expansion is often present. However, the outer rim of the tumor is always covered by periosteum and a thin rim of reactive bone. In the largest series reported, the size of osteoblastomas ranged from 1 to 11 cm, with a mean of 3.2 cm. 
As opposed to more their benign counterparts, aggressive osteoblastomas display aggressive destruction of the adjacent host bone cortex and extends into surrounding soft tissues. This characteristic is thought to be due to a coexisting aneurysmal bone cyst component.
The exact etiology of osteoblastoma is unknown.
In the United States, osteoblastoma accounts for approximately 1% of all primary bone tumors. The mean age at presentation in the largest series studied was 20.4 years, with a range of 6 months to 75 years.  The male-to-female patient ratio is 2:1.
Osteoblastoma has a reported recurrence rate of approximately 10-20%. Tumor relapse is associated with inadequate resection of the primary lesion. In some areas (eg, the spine), it might not always be possible to remove the entire lesion.
For stage 2 osteoblastomas (see Workup, Staging), however, the overall recurrence rate after extensive intralesional excision is close to 0%. The recurrence rate after excision through the reactive zone of the bone (marginal excision) is much higher. For an osteoblastoma associated with an aneurysmal bone cyst, the recurrence rate after wide excision in surgically accessible sites is reported as low, but no large-scale studies exist to define what “low” means. The recurrence rate after intralesional excision is higher at any site, as expected.
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Fred Ortmann, MD Orthopaedic Surgeon
Fred Ortmann, MD is a member of the following medical societies: Alpha Omega Alpha
Disclosure: Nothing to disclose.
John Eady, MD Chief of Orthopedic Surgery, Dorn Veterans Affairs Hospital
Disclosure: Nothing to disclose.
Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference
Disclosure: Received salary from Medscape for employment. for: Medscape.
Omohodion (Odion) Binitie, MD Medical Director, Assistant Member, Department of Sarcoma, Section Head, Orthopedics, Adolescent/Young Adult and Pediatric Orthopedic Oncology, Medical Director, Physical Therapy, Speech Therapy, and Rehabilitation Services, Assistant Fellowship Program Director, Musculoskeletal Oncology, Moffitt Cancer Center; Assistant Professor, Department of Oncologic Sciences, Department of Ortho and Sports Medicine, University of South Florida Morsani College of Medicine
Omohodion (Odion) Binitie, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons, Children’s Oncology Group, Florida Orthopaedic Society, Musculoskeletal Tumor Society
Disclosure: Nothing to disclose.
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