Lung Abscess Surgery

Lung Abscess Surgery

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A lung abscess is a subacute infection that destroys lung parenchyma. Furthermore, chest radiographs reveal one or more vities, often with an air-fluid level. Beuse the development of a vity requires some amount of prior tissue damage and necrosis, it may be presumed that lung abscesses usually begin as a lolized pneumonia.

Before the availability of antibiotics, a typil abscess arose from complitions after oral surgil procedures (ie, tonsillectomy), resulting in aspiration of infected material into the lungs. In the absence of satisfactory antibiotic treatment, this event usually led to a lung abscess or to a necrotizing pneumonia with or without pleural empyema.

In the preantibiotic era, the clinil course of a patient with a lung abscess would gradually worsen. At one , mortality was in excess of 50%, and many patients were left with signifint residual symptomatic disease. Most patients underwent surgery during the latter stages of the disease, and the results were discouraging.

The availability of effective antibiotic therapy for primary lung abscess has drastilly modified the natural history of the disease and diminished the role of surgery. In current practice, operative inditions are less frequent, and these procedures are undertaken electively for chronic es only after medil therapy has been unsuccessful.

In addition to antibiotics, pulmonary re has advanced and now includes postural drainage. Currently, bronchoscopy is ocsionally employed as an adjunct to expedite drainage and to identify underlying occult lesions such as foreign bodies and malignancies.

The increasing use of corticosteroids, immunosuppressive drugs, and chemotherapeutic agents has changed the natural milieu of the oropharyngeal vity and contributed to the mounting frequency of opportunistic lung abscesses.

Lung abscesses are commonly classified on the basis of their duration, as follows:

They may also be classified as follows:

For resources, see the Infections Center, Lung and Airway Center, Pneumonia Center, and Procedures Center, as well as Bacterial Pneumonia, Abscess, Antibiotics, and Bronchoscopy.

Aspiration of infectious material is the most frequent pathogenetic mechanism in the development of pyogenic lung abscess. Aspiration due to dysphagia (eg, achalasia) or to compromised consciousness (eg, alcoholism, seizure, cerebrovascular accident, or head ) appears to be a predisposing factor. Poor oral hygiene, dental infections, and gingival disease are also common in these patients.

Although lung abscesses n occur in edentulous patients, an occult rcinoma should be considered. Edentulous patients very seldom, if ever, develop a putrefied abscess, beuse they lack periodontal flora. [1]

Patients with alcoholism and those with chronic es frequently have oropharyngeal colonization with gram-negative bacteria, especially when they undergo prolonged endotracheal intubation and receive agents that neutralize gastric acidity. A pyogenic lung abscess n also develop from aspiration of infectious material from the oropharynx into the lung when the cough reflex is suppressed in a patient with gingivodental disease.

Abscesses generally develop in the right lung and involve the posterior segment of the right upper lobe, the superior segment of the lower lobe, or both. This is due to gravitation of the infectious material from the oropharynx into these dependent areas. Initially, the aspirated material settles in the distal bronchial system and develops into a lolized pneumonitis. Within 24-48 hours, a large area of inflammation results, consisting of exudate, blood, and necrotic lung tissue. The abscess frequently connects with a bronchus and partially empties.

After pyogenic pneumonitis develops in response to the aspirated infected material, liquefactive necrosis n occur secondary to bacterial proliferation and an inflammatory reaction to produce an acute abscess. As the liquefied necrotic material empties through the draining bronchus, a necrotic vity containing an air-fluid level is created. The infection may extend into the pleural space and produce an empyema without rupture of the abscess vity. The infectious process n also extend to the hilar and mediastinal lymph nodes, and these too may become purulent. (See the images below.)

Lung abscesses have numerous infectious uses. Anaerobic bacteria continue to be accountable for most ses. These bacteria predominate in the upper respiratory tract and are heavily concentrated in areas of oral-gingival disease. Other bacteria involved in lung abscesses are gram-positive and gram-negative organisms.

More specifilly, gram-negative organisms associated with lung abscess include the following:

Gram-positive organisms associated with lung abscess include the following:

Opportunistic organisms associated with lung abscess include the following:

However, lung vities may not always be due to an underlying infection. Some evidence suggests that individuals with cyanotic heart disorders may also be more prone to lung abscess formation. The continuous hypoperfusion of the pulmonary tissues may predispose the individuals to chronic pulmonary infections. [2]

Factors contributing to lung disease include the following:

The prognosis of patients with lung abscesses depends on the underlying or predisposing pathologic event and the speed with which appropriate therapy is established. Negative prognostic factors include the following:

The mortality associated with an anaerobic lung abscess is less than 15%, though it is slightly higher in patients with necrotizing anaerobic pneumonia and pneumonia used by gram-negative bacteria. The prognosis associated with amc lung abscess is good when treatment is prompt. Overall, lung abscess n have a better prognosis and shorter length of hospital admission if the diagnosis is made promptly and a consensus on antibiotics is available. [3]

Most ses of empyema have an infectious use and add high morbidity, as well as increase hospital costs. In patients who have empyema with a lung abscess, morbidity is even higher; hence, more aggressive early treatment is recommended. [4]

Over the years, numerous prognostic factors have been identified in patients with lung abscess. The two main factors are advanced age and the presence of comorbidity. The rate of reduction of the abscess is also felt to be predictive of recurrence. This again emphasizes the importance of follow-up with an imaging study, such as computed tomography (CT). [5]

In a study of 91 patients who underwent major thoracic surgery for infectious lung abscess at six centers for general thoracic surgery in Europe and and the United States, Schweigert et al found that the following were signifint predictors of fatal outcome [6] :

The extent of surgil resection was not found to have a signifint influence on the risk of a fatal outcome. [6]

Shinzato T. [Effects and management of odontogenic infections on pulmonary infections]. Yakugaku Zasshi. 2009 Dec. 129 (12):1461-4. [Medline].

O’Donnell CP, Landzberg MJ, Mullen MP. Lung abscess in adults with tetralogy of fallot and pulmonary atresia. rdiol Young. 2010 Feb. 20 (1):91-3. [Medline].

Magalhães L, Valadares D, Oliveira JR, Reis E. Lung abscesses: of 60 ses. Rev Port Pneumol. 2009 Mar-Apr. 15 (2):165-78. [Medline].

Huang HC, Chen HC, Fang HY, Lin YC, Wu CY, Cheng CY. Lung abscess predicts the surgil outcome in patients with pleural empyema. J rdiothorac Surg. 2010 Oct 20. 5:88. [Medline].

Ando K, Okhuni Y, Matsunuma R, Nakashima K, Iwasaki T, Asai N, et al. [Prognostic lung abscess factors]. Kansenshogaku Zasshi. 2010 Jul. 84 (4):425-30. [Medline].

Schweigert M, Solymosi N, Dubecz A, John J, West D, Boenisch PL, et al. Predictors of Outcome in Modern Surgery for Lung Abscess. Thorac rdiovasc Surg. 2017 Oct. 65 (7):535-541. [Medline].

Bartlett JG. Antibiotics in lung abscess. Semin Respir Infect. 1991 Jun. 6 (2):103-11. [Medline].

Unterman A, Fruchter O, Rosengarten D, Izhakian S, Abdel-Rahman N, Kramer MR. Bronchoscopic Drainage of Lung Abscesses Using a Pigtail theter. Respiration. 2017. 93 (2):99-105. [Medline].

Shlomi D, Kramer MR, Fs L, Peled N, Shitrit D. Endobronchial drainage of lung abscess: the use of laser. Snd J Infect Dis. 2010. 42 (1):65-8. [Medline].

vanSonnenberg E, D’Agostino HB, sola G, Wittich GR, Varney RR, Harker C. Lung abscess: CT-guided drainage. Radiology. 1991 Feb. 178 (2):347-51. [Medline].

Dunn C, Nadolski GJ, Gade T, Hunt S. Understanding the Lung Abscess Microbiome: Outcomes of Percutaneous Lung Parenchymal Abscess Drainage with Microbiologic Correlation. rdiovasc Intervent Radiol. 2017 Jun. 40 (6):902-906. [Medline].

Kelogrigoris M, Tsagouli P, Stathopoulos K, Tsagaridou I, Thanos L. CT-guided percutaneous drainage of lung abscesses: of 40 ses. JBR-BTR. 2011 Jul-Aug. 94 (4):191-5. [Medline].

Hecker E, Hamouri S, Müller E, Ewig S. [Pleural empyema and lung abscess: current treatment options]. Zentralbl Chir. 2012 Jun. 137 (3):248-56. [Medline].

Alifano M, Gaucher S, Rabbat A, Brandolini J, Guinet C, Damotte D, et al. Alternatives to resectional surgery for infectious disease of the lung: from embolization to thoracoplasty. Thorac Surg Clin. 2012 Aug. 22 (3):413-29. [Medline].

Sziklavari Z, Ried M, Hofmann HS. Vacuum-assisted closure therapy in the management of lung abscess. J rdiothorac Surg. 2014 Sep 6. 9:157. [Medline].

Sziklavari Z, Ried M, Hofmann HS. [Intrathoracic Vacuum-Assisted Closure in the Treatment of Pleural Empyema and Lung Abscess]. Zentralbl Chir. 2015 Jun. 140 (3):321-7. [Medline].

Nagasawa KK, Johnson SM. Thoracoscopic treatment of pediatric lung abscesses. J Pediatr Surg. 2010 Mar. 45 (3):574-8. [Medline].

Arai H, Inui K, Watanabe K, Watani K, Okudela K, Tsuboi M, et al. Lung abscess combined with chronic osteomyelitis of the mandible successfully treated with video-assisted thoracoscopic surgery. Clin Respir J. 2015 Apr. 9 (2):253-6. [Medline].

Shabir Bhimji, MD, PhD rdiothoracic and Vascular Surgeon, Saudi Arabia and Middle East Hospitals

Shabir Bhimji, MD, PhD is a member of the following medil societies: American Cancer Society, American College of Chest Physicians, American Lung Association, Texas Medical Association

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medil Center College of Pharmacy; Editor-in-Chief, Medspe Drug Reference

Disclosure: Received salary from Medspe for employment. for: Medspe.

Shreekanth V Karwande, MBBS Chair, Professor, Department of Surgery, Division of rdiothoracic Surgery, University of Utah School of Medicine and Medil Center

Shreekanth V Karwande, MBBS is a member of the following medil societies: American Association for Thoracic Surgery, American College of Chest Physicians, American College of Surgeons, American Heart Association, Society of Critical Care Medicine, Society of Thoracic Surgeons, Western Thoracic Surgical Association

Disclosure: Nothing to disclose.

rey C Milliken, MD Chief, Division of rdiothoracic Surgery, University of lifornia at Irvine Medil Center; Clinil Professor, Department of Surgery, University of lifornia, Irvine, School of Medicine

rey C Milliken, MD is a member of the following medil societies: Alpha Omega Alpha, American Association for Thoracic Surgery, American College of Cardiology, American College of Chest Physicians, American College of Surgeons, American Heart Association, American Society for Artificial Internal Organs, California Medical Association, International Society for Heart and Lung Transplantation, Phi Beta Kappa, Society of Thoracic Surgeons, SWOG, Western Surgical Association

Disclosure: Nothing to disclose.

Lung Abscess Surgery



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