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Chromosomal localization of human cellular homologues of two viral oncogenes

Chromosomal localization of human cellular homologues of two viral oncogenes

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Letter

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Published: 21 October 1982

Naturevolume 299pages747749
(1982)
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Acute transforming RNA tumour viruses represent genetic recombinants between type C retro viral sequences and transformation-specific sequences of cellular origin. Of the known mammalian cell-derived transforming genes (oncogenes), two have been shown to encode proteins with either intrinsic or highly associated tyrosine-specific protein kinase activity. One such gene, c-fes, is of cat cellular origin, while the second, c-abl, was derived from mouse cellular sequences. We now show that the human equivalents of c-fes and c-abl are localized on human chromosomes 15 and 9, respectively. These findings exclude the possibility that these transformation-related genes are clustered at a single locus within the human genome. It is of interest that both of these chromosomes are involved in specific rearrangements found in certain forms of human cancer.

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02 July 1982

25 August 1982

21 October 1982

https://doi.org/10.1038/299747a0

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