Aneurysmal Bone Cyst

Aneurysmal Bone Cyst

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As defined by the World Health Organization (WHO), the aneurysmal bone cyst (ABC) is a benign tumorlike lesion that is described as “an expanding osteolytic lesion consisting of blood-filled spaces of variable size separated by connective tissue septa containing trabeculae or osteoid tissue and osteoclast giant cells.” [1] It most often affects individuals during their second decade of life and may occur in any bone in the body. [2, 3, 4, 1, 5, 6, 7, 8, 9, 10, 11] Although benign, the ABC can be locally aggressive. Its expansile nature can cause pain, swelling, deformity, disruption of growth plates or joint surfaces, neurologic symptoms (depending on location), and pathologic fracture. [2, 3, 4]

Jaffe and Lichtenstein first described ABC as its own entity in 1942, when they noted “a peculiar blood-containing cyst of large size.” [12]  Two cases were reported in which a lesion with a “soap-bubble” appearance on radiographs was found on the superior pubic ramus of a 17-year-old male and on the second vertebra of an 18-year-old male. The lesions were expansile and showed evidence of erosion of the surrounding bone and encroachment of the surrounding tissues. Upon surgical exposure of the lesions, a thin, bony wall that contained bloody fluid was found.

Jaffe and Lichtenstein suggested that ABCs may have been mistaken for other benign and malignant bone tumors in the past. [12] Although ABC is a separate entity, in some situations, distinguishing an ABC from a giant cell tumor of bone or a telangiectatic osteosarcoma is difficult.

The true etiology and pathophysiology remain a mystery, but the mainstay of treatment has been intralesional curettage. [13] Recurrence is not uncommon. [2, 14] Other surgical options include en-bloc resection or wide excision, selective arterial embolization, and curettage with locally applied adjuvants such as liquid nitrogen, argon beam photocoagulation, or phenol.

Because ABCs may affect any bone in the body, the relevant surgical anatomy necessarily varies with location. The long tubular bones are the most common sites for ABCs, followed by the spine and the flat bones. These three areas account for 80% of all ABCs. When present in long tubular bones, ABCs tend to be eccentrically located in the metaphysis.

ABCs least commonly involve a subperiosteal location, where they may form a predominant soft-tissue mass. However, ABCs can occur in any location, including the diaphysis and epiphysis.

Rarely, ABCs have also been known to affect an adjacent bone; however, spinal ABCs are associated with a higher incidence of contiguous lesions. Almost all ABCs of the spine involve the posterior elements, and a high incidence of neurologic symptoms is observed, as well as more local aggressive behavior.

The pelvis accounts for approximately 50% of lesions occurring in the flat bones. [15] Secondary lesions tend to have a predilection for the areas of the body in which the primary lesion typically arises.

In a published review of 897 cases of ABC, the following rates of occurrence were reported [16] :

The true pathophysiology of ABCs is unknown. [13]

Different theories about several vascular malformations exist; these include arteriovenous fistulas and venous blockage. The vascular lesions then cause increased pressure, expansion, erosion, and resorption of the surrounding bone. The malformation is also believed to cause local hemorrhage that initiates the formation of reactive osteolytic tissue. Findings from a study in which manometric pressures within the ABCs were measured support the theory of altered hemodynamics.

Most primary ABCs demonstrate a t(16;17)(q22;p13) fusion of the TRE17/CDH11-USP6 oncogene. This fusion leads to increased cellular cadherin-11 activity that seems to arrest osteoblastic maturation in a more primitive state. [17] This process may be the neoplastic driving force behind primary ABCs as opposed to secondary ABCs, which seem to occur reactively as a result of another underlying disease process. [18]

The true etiology of ABCs is also unknown. Most investigators believe that ABCs are the result of a vascular malformation within the bone; however, the ultimate cause of the malformation is a topic of controversy. Three commonly proposed theories are as follows:

A certain percentage of primary ABCs may be truly neoplastic—as opposed to vascular, developmental, or reactive—phenomena. It has been shown that as many as 69% of primary ABCs demonstrate a characteristic clonal t(16;17) genetic translocation [19] leading to upregulation of the TRE17/USP6 oncogene, [17, 18] whereas no secondary ABCs demonstrate this cytogenetic aberration.

ABCs are generally considered rare, accounting for only 1-6% of all primary bony tumors. A group from Austria reported an annual incidence of 0.14 ABCs per 100,000 people [20] ; however, the true incidence is difficult to calculate because of the existence of spontaneous regression and clinically silent cases.

A biopsy-proven incidence study from the Netherlands showed that ABCs were the second most common tumor or tumorlike lesion found in children. [21]

Most studies have also found a slightly increased incidence in women. Although the ABC can appear in persons of any age, it is generally a disease of the young (albeit a rare one in the very young). About 50-70% of ABCs occur in the second decade of life, with 70-86% occurring in patients younger than 20 years. The mean patient age at onset is 13-17.7 years.

The prognosis for an ABC is generally excellent, though some patients need repeated treatments because of recurrence, which is the most common problem encountered when treating an ABC.

The overall cure rate is 90-95%. [22, 23]  A younger age, open growth plates, and a metaphyseal location all have been associated with an increased risk of recurrence. [22]  The stage of the ABC has not been shown to influence the rate of recurrence; however, most clinicians believe that Enneking/Musculoskeletal Tumor Society (MSTS) stage 3 lesions have the highest recurrence rate, other factors being equal. Capanna morphologic types I and II recur more often than types III, IV, and V.

Reported primary recurrence rates have varied greatly. Small studies have shown a benefit to using selective arterial embolization, and some authors advocate it as a first-line treatment. Other authors argue that not enough data on selective embolization exist and that surgery is the first-line treatment. Intralesional excision has the most data to suggest that it is a safe and effective method.

Recurrence rates for different techniques have varied. Some studies have reported recurrence rates as high as 59% with intralesional excision [24]  and as low as 0% with resection. [16]  In a summary of studies of different treatment methods, the following rates of recurrence were reported [16] :

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Nicholas Tedesco, DO Orthopedic Oncologist, Oregon Medical Group

Nicholas Tedesco, DO is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Medical Association, American Osteopathic Academy of Orthopedics, American Osteopathic Association, Musculoskeletal Tumor Society

Disclosure: Nothing to disclose.

Bart Eastwood, DO Orthopedic Surgeon and Sports Medicine Specialist, Sideline Orthopedics and Sports Medicine

Bart Eastwood, DO is a member of the following medical societies: American Academy of Orthopaedic Surgeons, American Orthopaedic Society for Sports Medicine, American Osteopathic Academy of Orthopedics, American Osteopathic Association, Arthroscopy Association of North America

Disclosure: Nothing to disclose.

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Harris Gellman, MD Consulting Surgeon, Broward Hand Center; Voluntary Clinical Professor of Orthopedic Surgery and Plastic Surgery, Departments of Orthopedic Surgery and Surgery, University of Miami, Leonard M Miller School of Medicine; Clinical Professor of Surgery, Nova Southeastern School of Medicine

Harris Gellman, MD is a member of the following medical societies: American Academy of Medical Acupuncture, American Academy of Orthopaedic Surgeons, American Orthopaedic Association, American Society for Surgery of the Hand, Arkansas Medical Society, Florida Medical Association, Florida Orthopaedic Society

Disclosure: Nothing to disclose.

Howard A Chansky, MD Associate Professor, Department of Orthopedics and Sports Medicine, University of Washington Medical Center

Howard A Chansky, MD is a member of the following medical societies: American Academy of Orthopaedic Surgeons

Disclosure: Nothing to disclose.

H Kurtis Biggs, DO Consulting Staff, Department of Orthopedics, Doctors Hospital of Stark County

Disclosure: Nothing to disclose.

Mark McFarland, DO Staff Physician, Department of Orthopedics, Doctors Hospital of Stark County

Disclosure: Nothing to disclose.

Aneurysmal Bone Cyst

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