Specific Gravity 

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Urinary specific gravity (SG) is a measure of the concentration of solutes in the urine. It measures the ratio of urine density compared with water density and provides information on the kidney’s ability to concentrate urine. A urinary specific gravity measurement is a routine part of urinalysis. [1, 2, 3] The reference range is 1.005-1.030. [3]

Conditions associated with a high urine specific gravity include the following [1, 4] :

Volume loss (dehydration, vomiting, diarrhea, fever)

Hepatorenal syndrome

Heart failure

Renal artery stenosis

Shock

Syndrome of inappropriate antidiuretic hormone

Conditions associated with a low urine specific gravity include the following [1, 4] :

Diabetes insipidus

Renal failure

Pyelonephritis

Glomerulonephritis

Psychogenic polydipsia

Malignant hypertension

Specifics for collection and panels are as follows [1, 4] :

Specimen type: Urine

Container: Plastic urine specimen container

Collection method: Random urine sample

Specimen volume: 20 mL

Panels: Urinalysis

Other instructions: Keep specimen cool; high temperatures alter the result

Related tests: Urine osmolality

Urinary specific gravity is a measure of the concentration of solutes in the urine and provides information on the kidney’s ability to concentrate urine. Urine osmolality is a more specific test for urine concentration; however, urine specific gravity measurement is a routine part of urinalysis.

Indications for testing urine specific gravity include the following:

Complicated urinary tract infection (eg, pyelonephritis)

Hypernatremia

Hyponatremia

Polyuria

Considerations  [4]

The following may increase urine specific gravity and should be discontinued before testing:

Dextran

Sucrose

Intravenous contrast dye

Daniels R. Delmar’s Guide to Laboratory and Diagnostic Tests. 2nd ed. Ashland, Oregon: Oregon Health and Science University; 2010.

McPherson RA, Pincus MR. Henry’s Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia: Elsevier Saunders; 2011.

Williamson MA, Snyder LM, eds. Wallach’s Interpretation of Diagnostic Tests. 9th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2011.

Fischbach F. Manual of Laboratory & Diagnostic Tests. 7th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2004.

Rugheed Ghadban, MD Assistant Professor, Division of Cardiovascular Medicine, University of Missouri-Columbia School of Medicine

Disclosure: Nothing to disclose.

Eric B Staros, MD Associate Professor of Pathology, St Louis University School of Medicine; Director of Clinical Laboratories, Director of Cytopathology, Department of Pathology, St Louis University Hospital

Eric B Staros, MD is a member of the following medical societies: American Medical Association, American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology

Disclosure: Nothing to disclose.

Judy Lin, MD

Disclosure: Nothing to disclose.

Specific Gravity 

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